On the mechanism of the antitumor activity of ferrocenium derivatives

Domenico Osella; Marco Ferrali; Piero Zanello; Franco Laschi; Marco Fontani; Carlo Nervi; Giorgio Cavigiolio

doi:10.1016/S0020-1693(00)00147-X

On the mechanism of the antitumor activity of ferrocenium derivatives

Domenico Osella, Marco Ferrali, Piero Zanello, Franco Laschi, Marco Fontani, Carlo Nervi, Giorgio Cavigiolio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Contradictory results exist in the literature about the antineoplastic activity of ferrocenes and their ferrocenium salts; additionally, little is known about the mechanism by which such drugs become active towards cancer cells. In the present paper we show that only ferrocenium species are able to inhibit the growth of Ehrlich ascites tumor cells in vivo and we propose that the cytotoxic activity of ferrocenium salts is not based on their direct linking to DNA, but on their ability to generate oxygen active species which induce oxidative DNA damage. (C) 2000 Elsevier Science S.A.

Lingua originale	Inglese
pagine (da-a)	42-48
Numero di pagine	7
Rivista	Inorganica Chimica Acta
Volume	306
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/S0020-1693(00)00147-X
Stato di pubblicazione	Pubblicato - 11 ago 2000
Pubblicato esternamente	Sì

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10.1016/S0020-1693(00)00147-X

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title = "On the mechanism of the antitumor activity of ferrocenium derivatives",

abstract = "Contradictory results exist in the literature about the antineoplastic activity of ferrocenes and their ferrocenium salts; additionally, little is known about the mechanism by which such drugs become active towards cancer cells. In the present paper we show that only ferrocenium species are able to inhibit the growth of Ehrlich ascites tumor cells in vivo and we propose that the cytotoxic activity of ferrocenium salts is not based on their direct linking to DNA, but on their ability to generate oxygen active species which induce oxidative DNA damage. (C) 2000 Elsevier Science S.A.",

keywords = "Antitumor agents, Ferrocenium complexes, Free radicals",

author = "Domenico Osella and Marco Ferrali and Piero Zanello and Franco Laschi and Marco Fontani and Carlo Nervi and Giorgio Cavigiolio",

note = "Funding Information: The present work arises from discussions originated in the ambit of the Consorzio MILES (Metals in Life & Environmental Sciences). M.F. and P.Z. gratefully acknowledge the financial support from the University of Siena (ex quota 60%), D.O. and C.N. that from CNR (Rome). We are indebted to Professor A. Giannetto (University of Messina) for the intercalation tests.",

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T1 - On the mechanism of the antitumor activity of ferrocenium derivatives

AU - Osella, Domenico

AU - Ferrali, Marco

AU - Zanello, Piero

AU - Laschi, Franco

AU - Fontani, Marco

AU - Nervi, Carlo

AU - Cavigiolio, Giorgio

N1 - Funding Information: The present work arises from discussions originated in the ambit of the Consorzio MILES (Metals in Life & Environmental Sciences). M.F. and P.Z. gratefully acknowledge the financial support from the University of Siena (ex quota 60%), D.O. and C.N. that from CNR (Rome). We are indebted to Professor A. Giannetto (University of Messina) for the intercalation tests.

PY - 2000/8/11

Y1 - 2000/8/11

N2 - Contradictory results exist in the literature about the antineoplastic activity of ferrocenes and their ferrocenium salts; additionally, little is known about the mechanism by which such drugs become active towards cancer cells. In the present paper we show that only ferrocenium species are able to inhibit the growth of Ehrlich ascites tumor cells in vivo and we propose that the cytotoxic activity of ferrocenium salts is not based on their direct linking to DNA, but on their ability to generate oxygen active species which induce oxidative DNA damage. (C) 2000 Elsevier Science S.A.

AB - Contradictory results exist in the literature about the antineoplastic activity of ferrocenes and their ferrocenium salts; additionally, little is known about the mechanism by which such drugs become active towards cancer cells. In the present paper we show that only ferrocenium species are able to inhibit the growth of Ehrlich ascites tumor cells in vivo and we propose that the cytotoxic activity of ferrocenium salts is not based on their direct linking to DNA, but on their ability to generate oxygen active species which induce oxidative DNA damage. (C) 2000 Elsevier Science S.A.

KW - Antitumor agents

KW - Ferrocenium complexes

KW - Free radicals

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U2 - 10.1016/S0020-1693(00)00147-X

DO - 10.1016/S0020-1693(00)00147-X

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VL - 306

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EP - 48

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - 1

ER -

On the mechanism of the antitumor activity of ferrocenium derivatives

Abstract

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