Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences

Lucio Toma, Diego Colombo, Fiamma Ronchetti, Luigi Panza, Giovanni Russo

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The conformational space of the tetrasaccharide α‐L‐Fuc‐(1→2)‐β‐D‐Gal‐(1→3)‐β‐D‐GalNAc‐(1→3)‐α‐D‐GallPr (3) and of some overlapping di‐ and trisaccharide sequences was investigated with the aid of molecular‐mechanics energy minimizations, molecular‐dynamics simulations, and 1H‐NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc‐Gal and Gal‐GalNAc) is combined with the flexibility of the third one (GalNAc‐Gal).

Lingua originaleInglese
pagine (da-a)636-646
Numero di pagine11
RivistaHelvetica Chimica Acta
Volume78
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 10 mag 1995
Pubblicato esternamente

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