Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.

N. Basilico; E. Bosisio; F. Buelli; G. Campiani; M. Casagrande; F. Castelli; P. Coghi; Y. Corbett; L. Cortelezzi; S. D'Alessandro; M. Dell'Agli; F. Esposito; C. Fattorusso; E. Fattorusso; S. Finaurini; G. V. Galli; S. Gemma; A. Habluetzel; L. Lucantoni; S. Melato; D. Monti; P. Olliaro; F. Omodeo-Salè; S. Parapini; M. Persico; M. Rizzi; S. Romeo; F. Rossi; C. Rusconi; A. Sparatore; O. Taglialatela Scafati; E. van den Bogaart; D. Taramelli; N. Vaiana; S. Yerbanga

Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.

N. Basilico, E. Bosisio, F. Buelli, G. Campiani, M. Casagrande, F. Castelli, P. Coghi, Y. Corbett, L. Cortelezzi, S. D'Alessandro, M. Dell'Agli, F. Esposito, C. Fattorusso, E. Fattorusso, S. Finaurini, G. V. Galli, S. Gemma, A. Habluetzel, L. Lucantoni, S. MelatoD. Monti, P. Olliaro, F. Omodeo-Salè, S. Parapini, M. Persico, M. Rizzi, S. Romeo, F. Rossi, C. Rusconi, A. Sparatore, O. Taglialatela Scafati, E. van den Bogaart, D. Taramelli, N. Vaiana, S. Yerbanga

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.

Lingua originale	Inglese
pagine (da-a)	133-136
Numero di pagine	4
Rivista	Parassitologia
Volume	50
Numero di pubblicazione	1-2
Stato di pubblicazione	Pubblicato - giu 2008
Pubblicato esternamente	Sì

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Basilico, N., Bosisio, E., Buelli, F., Campiani, G., Casagrande, M., Castelli, F., Coghi, P., Corbett, Y., Cortelezzi, L., D'Alessandro, S., Dell'Agli, M., Esposito, F., Fattorusso, C., Fattorusso, E., Finaurini, S., Galli, G. V., Gemma, S., Habluetzel, A., Lucantoni, L., ... Yerbanga, S. (2008). Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network. Parassitologia, 50(1-2), 133-136.

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title = "Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.",

abstract = "Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.",

author = "N. Basilico and E. Bosisio and F. Buelli and G. Campiani and M. Casagrande and F. Castelli and P. Coghi and Y. Corbett and L. Cortelezzi and S. D'Alessandro and M. Dell'Agli and F. Esposito and C. Fattorusso and E. Fattorusso and S. Finaurini and Galli, {G. V.} and S. Gemma and A. Habluetzel and L. Lucantoni and S. Melato and D. Monti and P. Olliaro and F. Omodeo-Sal{\`e} and S. Parapini and M. Persico and M. Rizzi and S. Romeo and F. Rossi and C. Rusconi and A. Sparatore and Scafati, {O. Taglialatela} and {van den Bogaart}, E. and D. Taramelli and N. Vaiana and S. Yerbanga",

year = "2008",

month = jun,

language = "English",

volume = "50",

pages = "133--136",

journal = "Parassitologia",

issn = "0048-2951",

number = "1-2",

}

Basilico, N, Bosisio, E, Buelli, F, Campiani, G, Casagrande, M, Castelli, F, Coghi, P, Corbett, Y, Cortelezzi, L, D'Alessandro, S, Dell'Agli, M, Esposito, F, Fattorusso, C, Fattorusso, E, Finaurini, S, Galli, GV, Gemma, S, Habluetzel, A, Lucantoni, L, Melato, S, Monti, D, Olliaro, P, Omodeo-Salè, F, Parapini, S, Persico, M, Rizzi, M, Romeo, S, Rossi, F, Rusconi, C, Sparatore, A, Scafati, OT, van den Bogaart, E, Taramelli, D, Vaiana, N & Yerbanga, S 2008, 'Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.', Parassitologia, vol. 50, n. 1-2, pagg. 133-136.

TY - JOUR

T1 - Old and new targets for innovative antimalarial compounds

T2 - the different strategies of the Italian Malaria Network.

AU - Basilico, N.

AU - Bosisio, E.

AU - Buelli, F.

AU - Campiani, G.

AU - Casagrande, M.

AU - Castelli, F.

AU - Coghi, P.

AU - Corbett, Y.

AU - Cortelezzi, L.

AU - D'Alessandro, S.

AU - Dell'Agli, M.

AU - Esposito, F.

AU - Fattorusso, C.

AU - Fattorusso, E.

AU - Finaurini, S.

AU - Galli, G. V.

AU - Gemma, S.

AU - Habluetzel, A.

AU - Lucantoni, L.

AU - Melato, S.

AU - Monti, D.

AU - Olliaro, P.

AU - Omodeo-Salè, F.

AU - Parapini, S.

AU - Persico, M.

AU - Rizzi, M.

AU - Romeo, S.

AU - Rossi, F.

AU - Rusconi, C.

AU - Sparatore, A.

AU - Scafati, O. Taglialatela

AU - van den Bogaart, E.

AU - Taramelli, D.

AU - Vaiana, N.

AU - Yerbanga, S.

PY - 2008/6

Y1 - 2008/6

N2 - Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.

AB - Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.

UR - http://www.scopus.com/inward/record.url?scp=56149085660&partnerID=8YFLogxK

M3 - Article

SN - 0048-2951

VL - 50

SP - 133

EP - 136

JO - Parassitologia

JF - Parassitologia

IS - 1-2

ER -

Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.

Abstract

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