Novelty-seeking in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: A case-control study

Secondo Fassino; Giovanni Abbate Daga; Carla Gramaglia; Andrea Pierò; Maurizio Zibetti; Lorys Castelli; Annina Cinquepalmi; Michele La Notte; Leonardo Lopiano

doi:10.1176/appi.psy.51.1.62

Novelty-seeking in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: A case-control study

Secondo Fassino, Giovanni Abbate Daga, Carla Gramaglia, Andrea Pierò, Maurizio Zibetti, Lorys Castelli, Annina Cinquepalmi, Michele La Notte, Leonardo Lopiano

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%. Objective: The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects. Method: Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D). Results: Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients. Conclusion: Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.

Lingua originale	Inglese
pagine (da-a)	62-67
Numero di pagine	6
Rivista	Psychosomatics
Volume	51
Numero di pubblicazione	1
DOI	https://doi.org/10.1176/appi.psy.51.1.62
Stato di pubblicazione	Pubblicato - 2010
Pubblicato esternamente	Sì

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abstract = "Background: The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%. Objective: The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects. Method: Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D). Results: Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients. Conclusion: Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.",

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AU - Fassino, Secondo

AU - Daga, Giovanni Abbate

AU - Gramaglia, Carla

AU - Pierò, Andrea

AU - Zibetti, Maurizio

AU - Castelli, Lorys

AU - Cinquepalmi, Annina

AU - La Notte, Michele

AU - Lopiano, Leonardo

PY - 2010

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N2 - Background: The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%. Objective: The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects. Method: Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D). Results: Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients. Conclusion: Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.

AB - Background: The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%. Objective: The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects. Method: Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D). Results: Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients. Conclusion: Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.

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Novelty-seeking in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: A case-control study

Abstract

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