Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Chiara di Meo; Luigi Panza; Federica Campo; Donatella Capitani; Luisa Mannina; Alessandra Banzato; Maria Rondina; Antonio Rosato; Vittorio Crescenzi

doi:10.1002/mabi.200700304

Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Chiara di Meo, Luigi Panza, Federica Campo, Donatella Capitani, Luisa Mannina, Alessandra Banzato, Maria Rondina, Antonio Rosato, Vittorio Crescenzi

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.

Lingua originale	Inglese
pagine (da-a)	670-681
Numero di pagine	12
Rivista	Macromolecular Bioscience
Volume	8
Numero di pubblicazione	7
DOI	https://doi.org/10.1002/mabi.200700304
Stato di pubblicazione	Pubblicato - 7 lug 2008

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abstract = "Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.",

keywords = "BNCT, Biological applications of polymers, Click chemistry, Conjugated polymers, Hyaluronan",

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AU - di Meo, Chiara

AU - Panza, Luigi

AU - Campo, Federica

AU - Capitani, Donatella

AU - Mannina, Luisa

AU - Banzato, Alessandra

AU - Rondina, Maria

AU - Rosato, Antonio

AU - Crescenzi, Vittorio

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N2 - Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.

AB - Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.

KW - BNCT

KW - Biological applications of polymers

KW - Click chemistry

KW - Conjugated polymers

KW - Hyaluronan

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Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Abstract

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