Keyphrases
Colchicine Binding Site
100%
Binder
100%
Microtubule-stabilizing Agents
100%
Tubulin
80%
X-ray Crystallography
40%
Crystallographic Fragment Screening
40%
Microtubules
40%
Screening Approach
40%
Tubulin Binding
40%
Binding Fragment
40%
Small Molecules
20%
Rationally Designed
20%
Cell Death
20%
Low Affinity
20%
Immunostaining
20%
Cell Viability
20%
Chemotherapy
20%
Molecular Mechanism
20%
Antitubulin
20%
HeLa Cells
20%
Antitumor Activity
20%
Cytoskeleton
20%
IC50
20%
Computer-aided Drug Design
20%
Targeted Agents
20%
Structure-activity Relationship Studies
20%
Cell Cycle Arrest
20%
Microtubule Dynamics
20%
Lead-like
20%
Microtubule Destabilization
20%
Fragment Growing
20%
Antimitotic Activity
20%
X-ray Computer
20%
2-Aminobenzothiazole Derivatives
20%
Microtubule-targeting Agents
20%
Medicine and Dentistry
Tubulin
100%
Microtubule
100%
Colchicine
100%
Binding Site
66%
X-Ray Crystallography
33%
Immunohistochemistry
16%
Cell Viability
16%
Cell Death
16%
Antineoplastic Activity
16%
Cytoskeleton
16%
Cell Cycle Arrest
16%
IC50
16%
Structure-Activity Relationship
16%
Cell Cycle Checkpoint
16%
Drug Action
16%
Chemistry
Microtubule-Destabilising Agent
100%
Colchicine
100%
Binding Site
80%
X-Ray Crystallography
40%
Polymerization
20%
Structure-Activity Relationship
20%
Cell Viability
20%
Antitumor
20%
IC50
20%
Filament
20%
Antimitotic
20%
2-Aminobenzimidazole
20%
Binding Agent
20%
Cell Death
20%
Biochemistry, Genetics and Molecular Biology
Tubulin
100%
Binding Site
66%
X-Ray Crystallography
33%
Small Molecule
16%
Cell Death
16%
Cell Viability
16%
Immunostaining
16%
Structure Activity Relation
16%
Antineoplastic Activity
16%
Dynamics
16%
Cytoskeleton
16%
IC50
16%
Cell Cycle Arrest
16%
Cell Cycle Checkpoint
16%
Computer-Aided Drug Design
16%
Drug Mechanism
16%
Pharmacology, Toxicology and Pharmaceutical Science
Tubulin
100%
Colchicine
100%
Binding Site
66%
Drug Action
16%
Structure Activity Relationship
16%
Cell Viability
16%
Chemotherapy
16%
Antitumor Activity
16%
Computer-Aided Drug Design
16%
IC50
16%