TY - JOUR
T1 - Not all Shc's roads lead to Ras
AU - Bonfini, Laura
AU - Migliaccio, Enrica
AU - Pelicci, Giuliana
AU - Lanfrancone, Luisa
AU - Pelicci, Pier Giuseppe
N1 - Funding Information:
The experimental work from our lab oratory cited in this review has been supported by grants from AIRC and HFSPO.
PY - 1996/7
Y1 - 1996/7
N2 - The Shc proteins have been implicated in the Ras signaling pathway by virtue of their association with the Grb2 adaptor molecule. Several lines of evidence indicate that this association is indeed involved in Ras activation. More recent experiments in mammalian tissue culture cells suggest that domains unique to Shc isoforms, named CH1 and CH2, might be involved in a new network of protein-protein interactions, and hint at other roles that Shc might play in addition to Ras activation.
AB - The Shc proteins have been implicated in the Ras signaling pathway by virtue of their association with the Grb2 adaptor molecule. Several lines of evidence indicate that this association is indeed involved in Ras activation. More recent experiments in mammalian tissue culture cells suggest that domains unique to Shc isoforms, named CH1 and CH2, might be involved in a new network of protein-protein interactions, and hint at other roles that Shc might play in addition to Ras activation.
UR - http://www.scopus.com/inward/record.url?scp=0030199613&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(96)10033-5
DO - 10.1016/S0968-0004(96)10033-5
M3 - Review article
SN - 0968-0004
VL - 21
SP - 257
EP - 261
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 7
ER -