TY - JOUR
T1 - Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1–T2 N0 M0) Perianal Squamous Cell Carcinoma
T2 - A Narrative Clinical Review and Critical Appraisal
AU - Spinelli, Lavinia
AU - Martini, Stefania
AU - Solla, Salvatore Dario
AU - Vigna Taglianti, Riccardo
AU - Olivero, Francesco
AU - Gianello, Luca
AU - Reali, Alessia
AU - Merlotti, Anna Maria
AU - Franco, Pierfrancesco
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12
Y1 - 2023/12
N2 - Distinction between anal canal and perianal squamous cell carcinomas (pSCCs) is essential, as these two subgroups have different anatomical, histological, and lymphatic drainage features. Early-stage true perianal tumors are very uncommon and have been rarely included in clinical trials. Perianal skin cancers and aCCs are included in the same tumor classification, even though they have different lymphatic drainage features. Furthermore, pSCCs are treated similarly to carcinomas originating from the anal canal. Radiation therapy (RT) is an essential treatment for anal canal tumors. Guidelines do not differentiate between treatment volumes for perianal tumors and anal cancers. So far, in pSCC, no study has considered modulating treatment volume selection according to the stage of the disease. We conducted a narrative literature review to describe the sites at higher risk for microscopic disease in patients with early-stage perianal cancers (T1–T2 N0 M0) to propose a well-thought selection of RT elective volumes.
AB - Distinction between anal canal and perianal squamous cell carcinomas (pSCCs) is essential, as these two subgroups have different anatomical, histological, and lymphatic drainage features. Early-stage true perianal tumors are very uncommon and have been rarely included in clinical trials. Perianal skin cancers and aCCs are included in the same tumor classification, even though they have different lymphatic drainage features. Furthermore, pSCCs are treated similarly to carcinomas originating from the anal canal. Radiation therapy (RT) is an essential treatment for anal canal tumors. Guidelines do not differentiate between treatment volumes for perianal tumors and anal cancers. So far, in pSCC, no study has considered modulating treatment volume selection according to the stage of the disease. We conducted a narrative literature review to describe the sites at higher risk for microscopic disease in patients with early-stage perianal cancers (T1–T2 N0 M0) to propose a well-thought selection of RT elective volumes.
KW - anal cancer
KW - contouring
KW - narrative review
KW - perianal squamous cell carcinoma
KW - radiotherapy
KW - treatment volumes
UR - http://www.scopus.com/inward/record.url?scp=85180732647&partnerID=8YFLogxK
U2 - 10.3390/cancers15245833
DO - 10.3390/cancers15245833
M3 - Review article
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 24
M1 - 5833
ER -