Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1–T2 N0 M0) Perianal Squamous Cell Carcinoma: A Narrative Clinical Review and Critical Appraisal

Lavinia Spinelli, Stefania Martini, Salvatore Dario Solla, Riccardo Vigna Taglianti, Francesco Olivero, Luca Gianello, Alessia Reali, Anna Maria Merlotti, Pierfrancesco Franco

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

Distinction between anal canal and perianal squamous cell carcinomas (pSCCs) is essential, as these two subgroups have different anatomical, histological, and lymphatic drainage features. Early-stage true perianal tumors are very uncommon and have been rarely included in clinical trials. Perianal skin cancers and aCCs are included in the same tumor classification, even though they have different lymphatic drainage features. Furthermore, pSCCs are treated similarly to carcinomas originating from the anal canal. Radiation therapy (RT) is an essential treatment for anal canal tumors. Guidelines do not differentiate between treatment volumes for perianal tumors and anal cancers. So far, in pSCC, no study has considered modulating treatment volume selection according to the stage of the disease. We conducted a narrative literature review to describe the sites at higher risk for microscopic disease in patients with early-stage perianal cancers (T1–T2 N0 M0) to propose a well-thought selection of RT elective volumes.

Lingua originaleInglese
Numero di articolo5833
RivistaCancers
Volume15
Numero di pubblicazione24
DOI
Stato di pubblicazionePubblicato - dic 2023

Fingerprint

Entra nei temi di ricerca di 'Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1–T2 N0 M0) Perianal Squamous Cell Carcinoma: A Narrative Clinical Review and Critical Appraisal'. Insieme formano una fingerprint unica.

Cita questo