No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Isabella Fogh; Sandra D'Alfonso; Cinzia Gellera; Antonia Ratti; Cristina Cereda; Silvana Penco; Lucia Corrado; Gianni Sorar; Barbara Castellotti; Cinzia Tiloca; Stella Gagliardi; Lorena Cozzi; Michelle K. Lupton; Nicola Ticozzi; Letizia Mazzini; Chris E. Shaw; Ammar Al-Chalabi; John Powell; Vincenzo Silani

doi:10.1016/j.neurobiolaging.2009.05.014

No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Isabella Fogh, Sandra D'Alfonso, Cinzia Gellera, Antonia Ratti, Cristina Cereda, Silvana Penco, Lucia Corrado, Gianni Sorar, Barbara Castellotti, Cinzia Tiloca, Stella Gagliardi, Lorena Cozzi, Michelle K. Lupton, Nicola Ticozzi, Letizia Mazzini, Chris E. Shaw, Ammar Al-Chalabi, John Powell, Vincenzo Silani

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

Lingua originale	Inglese
pagine (da-a)	966-967
Numero di pagine	2
Rivista	Neurobiology of Aging
Volume	32
Numero di pubblicazione	5
DOI	https://doi.org/10.1016/j.neurobiolaging.2009.05.014
Stato di pubblicazione	Pubblicato - mag 2011

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10.1016/j.neurobiolaging.2009.05.014

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Fogh, I., D'Alfonso, S., Gellera, C., Ratti, A., Cereda, C., Penco, S., Corrado, L., Sorar, G., Castellotti, B., Tiloca, C., Gagliardi, S., Cozzi, L., Lupton, M. K., Ticozzi, N., Mazzini, L., Shaw, C. E., Al-Chalabi, A., Powell, J., & Silani, V. (2011). No association of DPP6 with amyotrophic lateral sclerosis in an Italian population. Neurobiology of Aging, 32(5), 966-967. https://doi.org/10.1016/j.neurobiolaging.2009.05.014

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title = "No association of DPP6 with amyotrophic lateral sclerosis in an Italian population",

abstract = "We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.",

keywords = "Amyotrophic lateral sclerosis, Dipeptidyl-peptidase 6 (DPP6) gene, Genome-wide association study, Polymorphism",

author = "Isabella Fogh and Sandra D'Alfonso and Cinzia Gellera and Antonia Ratti and Cristina Cereda and Silvana Penco and Lucia Corrado and Gianni Sorar and Barbara Castellotti and Cinzia Tiloca and Stella Gagliardi and Lorena Cozzi and Lupton, {Michelle K.} and Nicola Ticozzi and Letizia Mazzini and Shaw, {Chris E.} and Ammar Al-Chalabi and John Powell and Vincenzo Silani",

year = "2011",

month = may,

doi = "10.1016/j.neurobiolaging.2009.05.014",

language = "English",

volume = "32",

pages = "966--967",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "5",

}

Fogh, I, D'Alfonso, S, Gellera, C, Ratti, A, Cereda, C, Penco, S, Corrado, L, Sorar, G, Castellotti, B, Tiloca, C, Gagliardi, S, Cozzi, L, Lupton, MK, Ticozzi, N, Mazzini, L, Shaw, CE, Al-Chalabi, A, Powell, J & Silani, V 2011, 'No association of DPP6 with amyotrophic lateral sclerosis in an Italian population', Neurobiology of Aging, vol. 32, n. 5, pagg. 966-967. https://doi.org/10.1016/j.neurobiolaging.2009.05.014

TY - JOUR

T1 - No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

AU - Fogh, Isabella

AU - D'Alfonso, Sandra

AU - Gellera, Cinzia

AU - Ratti, Antonia

AU - Cereda, Cristina

AU - Penco, Silvana

AU - Corrado, Lucia

AU - Sorar, Gianni

AU - Castellotti, Barbara

AU - Tiloca, Cinzia

AU - Gagliardi, Stella

AU - Cozzi, Lorena

AU - Lupton, Michelle K.

AU - Ticozzi, Nicola

AU - Mazzini, Letizia

AU - Shaw, Chris E.

AU - Al-Chalabi, Ammar

AU - Powell, John

AU - Silani, Vincenzo

PY - 2011/5

Y1 - 2011/5

N2 - We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

AB - We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

KW - Amyotrophic lateral sclerosis

KW - Dipeptidyl-peptidase 6 (DPP6) gene

KW - Genome-wide association study

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=79954570110&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2009.05.014

DO - 10.1016/j.neurobiolaging.2009.05.014

M3 - Article

SN - 0197-4580

VL - 32

SP - 966

EP - 967

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 5

ER -

No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Abstract

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