Abstract
Dental pulp is the specialized tissue responsible for maintaining tooth viability. When tooth mineralized matrix is damaged, pulp is exposed to a plethora of environmental stimuli. In particular, in smokers, pulp become exposed to very high concentrations of nicotine. The aim of this study was to investigate the effect of direct nicotine stimulation on human dental pulp cell proliferation. Moreover, as it is known that nicotine could upregulate the expression of matrix metalloproteinases (MMPs), enzymes involved in pulpal inflammation, the effects of nicotine stimulation on MMP-2 and MMP-28 gene expression have also been investigated.
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | 49-54 |
| Numero di pagine | 6 |
| Rivista | Life Sciences |
| Volume | 135 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2015 |
Keywords
- Adolescent
- Adult
- Cell Proliferation
- Cells, Cultured
- Dental Pulp
- Dental pulp
- Female
- Flavonoids
- Ganglionic Blockers
- Ganglionic Stimulants
- Gene Expression Regulation, Enzymologic
- Hexamethonium
- Hexamethonium chloride
- Humans
- MAP Kinase Kinase Kinases
- MAP Kinase Signaling System
- MAPK
- MMPs
- Male
- Matrix Metalloproteinase 2
- Matrix Metalloproteinases, Secreted
- Nicotine
- Up-Regulation
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