TY - JOUR
T1 - Nicergoline reverts haloperidol-induced loss of detoxifying-enzyme activity
AU - Vairetti, Mariapia
AU - Ferrigno, Andrea
AU - Canonico, Pier Luigi
AU - Battaglia, Angelo
AU - Bertè, Francantonio
AU - Richelmi, Plinio
PY - 2004/11/28
Y1 - 2004/11/28
N2 - We evaluated the effects of nicergoline on antioxidant defense enzymes (detoxifying enzymes), during chronic treatment with haloperidol in rats. Chronic use of haloperidol (10 weeks, 1.5 mg/kg/day) induces a significant decrease in glutathione reductase, glutathione peroxidase and superoxide dismutase activity, in selected areas of the brain. Co-administration of nicergoline (20 days, 10 mg/kg/day) significantly restored the activity of these enzymes to levels comparable to those observed in control rats. These observations suggest beneficial effects of nicergoline in the prevention and in the treatment of haloperidol-induced side effects.
AB - We evaluated the effects of nicergoline on antioxidant defense enzymes (detoxifying enzymes), during chronic treatment with haloperidol in rats. Chronic use of haloperidol (10 weeks, 1.5 mg/kg/day) induces a significant decrease in glutathione reductase, glutathione peroxidase and superoxide dismutase activity, in selected areas of the brain. Co-administration of nicergoline (20 days, 10 mg/kg/day) significantly restored the activity of these enzymes to levels comparable to those observed in control rats. These observations suggest beneficial effects of nicergoline in the prevention and in the treatment of haloperidol-induced side effects.
KW - Glutathione peroxidase
KW - Glutathione reductase
KW - Haloperidol
KW - Nicergoline
KW - Superoxide dismutase
UR - http://www.scopus.com/inward/record.url?scp=8844256590&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2004.10.016
DO - 10.1016/j.ejphar.2004.10.016
M3 - Article
SN - 0014-2999
VL - 505
SP - 121
EP - 125
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -