New structures of allosteric proteins revealing remarkable conformational changes

Andrea Mattevi, Menico Rizzi, Martino Bolognesi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

New three-dimensional structures of allosteric proteins reveal they have a flexible architecture that is instrumental to the regulation of protein function. Highlights are the structures of GroEL, pyruvate kinase, D-9-phosphoglycerate dehydrogenase and the acetylcholine receptor. Furthermore, significant progress in understanding the nature of the intermediates involved in an allosteric reaction has been achieved through recent spectroscopic and crystallographic studies on haemoglobin.

Lingua originaleInglese
pagine (da-a)824-829
Numero di pagine6
RivistaCurrent Opinion in Structural Biology
Volume6
Numero di pubblicazione6
DOI
Stato di pubblicazionePubblicato - dic 1996
Pubblicato esternamente

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