New potential uroselective NO-donor α1-antagonists

Donatella Boschi; Gian Cesare Tron; Antonella Di Stilo; Roberta Fruttero; Alberto Gasco; Elena Poggesi; Gianni Motta; Amedeo Leonardi

doi:10.1021/jm030825u

New potential uroselective NO-donor α₁-antagonists

Donatella Boschi
, Gian Cesare Tron
, Antonella Di Stilo
, Roberta Fruttero
, Alberto Gasco
, Elena Poggesi
, Gianni Motta
, Amedeo Leonardi

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A recent uroselective α₁-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α₁-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α _1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α_1A-antagonist and their NO-donor properties.

Lingua originale	Inglese
pagine (da-a)	3762-3765
Numero di pagine	4
Rivista	Journal of Medicinal Chemistry
Volume	46
Numero di pubblicazione	17
DOI	https://doi.org/10.1021/jm030825u
Stato di pubblicazione	Pubblicato - 14 ago 2003

Accesso al documento

10.1021/jm030825u

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{f701e40d663c412ebc193e307e3a8e52,

title = "New potential uroselective NO-donor α1-antagonists",

abstract = "A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.",

author = "Donatella Boschi and Tron, \{Gian Cesare\} and \{Di Stilo\}, Antonella and Roberta Fruttero and Alberto Gasco and Elena Poggesi and Gianni Motta and Amedeo Leonardi",

year = "2003",

month = aug,

day = "14",

doi = "10.1021/jm030825u",

language = "English",

volume = "46",

pages = "3762--3765",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - New potential uroselective NO-donor α1-antagonists

AU - Boschi, Donatella

AU - Tron, Gian Cesare

AU - Di Stilo, Antonella

AU - Fruttero, Roberta

AU - Gasco, Alberto

AU - Poggesi, Elena

AU - Motta, Gianni

AU - Leonardi, Amedeo

PY - 2003/8/14

Y1 - 2003/8/14

N2 - A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.

AB - A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.

UR - https://www.scopus.com/pages/publications/0043068109

U2 - 10.1021/jm030825u

DO - 10.1021/jm030825u

M3 - Article

SN - 0022-2623

VL - 46

SP - 3762

EP - 3765

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 17