New potential uroselective NO-donor α1-antagonists

Donatella Boschi; Gian Cesare Tron; Antonella Di Stilo; Roberta Fruttero; Alberto Gasco; Elena Poggesi; Gianni Motta; Amedeo Leonardi

doi:10.1021/jm030825u

New potential uroselective NO-donor α₁-antagonists

Donatella Boschi, Gian Cesare Tron, Antonella Di Stilo, Roberta Fruttero, Alberto Gasco, Elena Poggesi, Gianni Motta, Amedeo Leonardi

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A recent uroselective α₁-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α₁-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α _1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α_1A-antagonist and their NO-donor properties.

Lingua originale	Inglese
pagine (da-a)	3762-3765
Numero di pagine	4
Rivista	Journal of Medicinal Chemistry
Volume	46
Numero di pubblicazione	17
DOI	https://doi.org/10.1021/jm030825u
Stato di pubblicazione	Pubblicato - 14 ago 2003

Accesso al documento

10.1021/jm030825u

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abstract = "A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.",

author = "Donatella Boschi and Tron, {Gian Cesare} and {Di Stilo}, Antonella and Roberta Fruttero and Alberto Gasco and Elena Poggesi and Gianni Motta and Amedeo Leonardi",

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T1 - New potential uroselective NO-donor α1-antagonists

AU - Boschi, Donatella

AU - Tron, Gian Cesare

AU - Di Stilo, Antonella

AU - Fruttero, Roberta

AU - Gasco, Alberto

AU - Poggesi, Elena

AU - Motta, Gianni

AU - Leonardi, Amedeo

PY - 2003/8/14

Y1 - 2003/8/14

N2 - A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.

AB - A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned α 1a-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their α1A-antagonist and their NO-donor properties.

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M3 - Article

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JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 17