Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii

Weidong He, Miroslav Cik, Luc Van Puyvelde, Jacky Van Dun, Giovanni Appendino, Anne Lesage, Ilse Van der Lindin, Josée E. Leysen, Walter Wouters, Simon G. Mathenge, Francis P. Mudida, Norbert De Kimpe

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial anti-leukaemia activitie of the these compound were found in in vitro assay.

Lingua originaleInglese
pagine (da-a)3245-3255
Numero di pagine11
RivistaBioorganic and Medicinal Chemistry
Volume10
Numero di pubblicazione10
DOI
Stato di pubblicazionePubblicato - 2002
Pubblicato esternamente

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