Neuronal modulation in the prefrontal cortex in a transitive inference task: Evidence of neuronal correlates of mental schema management

Emiliano Brunamonti, Valentina Mione, Fabio di Bello, Pierpaolo Pani, Aldo Genovesio, Stefano Ferraina

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

When informed that A > B and B > C, humans and other animals can easily conclude that A > C. This remarkable trait of advanced animals, which allows them to manipulate knowledge flexibly to infer logical relations, has only recently garnered interest in mainstream neuroscience. How the brain controls these logical processes remains an unanswered question that has been merely superficially addressed in neuroimaging and lesion studies, which are unable to identify the underlying neuronal computations. We observed that the activation pattern of neurons in the prefrontal cortex (PFC) during pair comparisons in a highly demanding transitive inference task fully supports the behavioral performance of the two monkeys that we tested. Our results indicate that the PFC contributes to the construction and use of a mental schema to represent premises. This evidence provides a novel framework for understanding the function of various areas of brain in logic processes and impairments to them in degenerative, traumatic, and psychiatric pathologies.

Lingua originaleInglese
pagine (da-a)1223-1236
Numero di pagine14
RivistaJournal of Neuroscience
Volume36
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 27 gen 2016
Pubblicato esternamente

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