Neuroinflammation and hypothalamo-pituitary dysfunction: Focus of traumatic brain injury

Chiara Mele; Valeria Pingue; Marina Caputo; Marco Zavattaro; Loredana Pagano; Flavia Prodam; Antonio Nardone; Gianluca Aimaretti; Paolo Marzullo

doi:10.3390/ijms22052686

Neuroinflammation and hypothalamo-pituitary dysfunction: Focus of traumatic brain injury

Chiara Mele, Valeria Pingue, Marina Caputo, Marco Zavattaro, Loredana Pagano, Flavia Prodam, Antonio Nardone, Gianluca Aimaretti, Paolo Marzullo

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

The incidence of traumatic brain injury (TBI) has increased over the last years with an important impact on public health. Many preclinical and clinical studies identified multiple and heterogeneous TBI-related pathophysiological mechanisms that are responsible for functional, cognitive, and behavioral alterations. Recent evidence has suggested that post-TBI neuroinflammation is responsible for several long-term clinical consequences, including hypopituitarism. This review aims to summarize current evidence on TBI-induced neuroinflammation and its potential role in determining hypothalamic-pituitary dysfunctions.

Lingua originale	Inglese
Numero di articolo	2686
pagine (da-a)	1-22
Numero di pagine	22
Rivista	International Journal of Molecular Sciences
Volume	22
Numero di pubblicazione	5
DOI	https://doi.org/10.3390/ijms22052686
Stato di pubblicazione	Pubblicato - 1 mar 2021

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10.3390/ijms22052686

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abstract = "The incidence of traumatic brain injury (TBI) has increased over the last years with an important impact on public health. Many preclinical and clinical studies identified multiple and heterogeneous TBI-related pathophysiological mechanisms that are responsible for functional, cognitive, and behavioral alterations. Recent evidence has suggested that post-TBI neuroinflammation is responsible for several long-term clinical consequences, including hypopituitarism. This review aims to summarize current evidence on TBI-induced neuroinflammation and its potential role in determining hypothalamic-pituitary dysfunctions.",

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author = "Chiara Mele and Valeria Pingue and Marina Caputo and Marco Zavattaro and Loredana Pagano and Flavia Prodam and Antonio Nardone and Gianluca Aimaretti and Paolo Marzullo",

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AU - Mele, Chiara

AU - Pingue, Valeria

AU - Caputo, Marina

AU - Zavattaro, Marco

AU - Pagano, Loredana

AU - Prodam, Flavia

AU - Nardone, Antonio

AU - Aimaretti, Gianluca

AU - Marzullo, Paolo

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N2 - The incidence of traumatic brain injury (TBI) has increased over the last years with an important impact on public health. Many preclinical and clinical studies identified multiple and heterogeneous TBI-related pathophysiological mechanisms that are responsible for functional, cognitive, and behavioral alterations. Recent evidence has suggested that post-TBI neuroinflammation is responsible for several long-term clinical consequences, including hypopituitarism. This review aims to summarize current evidence on TBI-induced neuroinflammation and its potential role in determining hypothalamic-pituitary dysfunctions.

AB - The incidence of traumatic brain injury (TBI) has increased over the last years with an important impact on public health. Many preclinical and clinical studies identified multiple and heterogeneous TBI-related pathophysiological mechanisms that are responsible for functional, cognitive, and behavioral alterations. Recent evidence has suggested that post-TBI neuroinflammation is responsible for several long-term clinical consequences, including hypopituitarism. This review aims to summarize current evidence on TBI-induced neuroinflammation and its potential role in determining hypothalamic-pituitary dysfunctions.

KW - Hypopituitarism

KW - Neuroinflammation

KW - Traumatic brain injury

UR - https://www.scopus.com/pages/publications/85101987123

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DO - 10.3390/ijms22052686

M3 - Review article

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Neuroinflammation and hypothalamo-pituitary dysfunction: Focus of traumatic brain injury

Abstract

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