NAADP: An atypical Ca2+-release messenger?

Armando A. Genazzani; Richard A. Billington

doi:10.1016/S0165-6147(00)01990-8

NAADP: An atypical Ca²⁺-release messenger?

Armando A. Genazzani, Richard A. Billington

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca²⁺ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca²⁺ signalling by coordinating the responses of other Ca²⁺-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.

Lingua originale	Inglese
pagine (da-a)	165-167
Numero di pagine	3
Rivista	Trends in Pharmacological Sciences
Volume	23
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/S0165-6147(00)01990-8
Stato di pubblicazione	Pubblicato - 1 apr 2002
Pubblicato esternamente	Sì

Accesso al documento

10.1016/S0165-6147(00)01990-8

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title = "NAADP: An atypical Ca2+-release messenger?",

abstract = "Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other Ca2+-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.",

author = "Genazzani, {Armando A.} and Billington, {Richard A.}",

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N2 - Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other Ca2+-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.

AB - Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other Ca2+-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.

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DO - 10.1016/S0165-6147(00)01990-8

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