Multivalent, saccharide-functionalized gold nanoparticles as fully synthetic analogs of type a Neisseria meningitidis antigens

Flavio Manea, Cristiano Bindoli, Silvia Fallarini, Grazia Lombardi, Laura Polito, Luigi Lay, Renato Bonomi, Fabrizio Mancin, Paolo Scrimin

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A study was conducted to demonstrate multivalent, saccharide-functionalized gold nanoparticles as fully synthetic analogs of type A Neisseria meningitidis antigens. The study demonstrated that the type A Neisseria meningitidis antigens bind to mouse polyclonal antibodies effectively. ELISA investigations were conducted that revealed that nanoparticles appear to be more powerful and effective than the oligomeric saccharides. The study also highlighted the comparative advantages of the self-assembled process and the covalent oligomerization. Transmission electron microscopy (TEM) images for nanoparticles size determination were recorded on a copper grid, using a Jeol 300PX instrument. Thiols 2 and 7, along with saccharides were also prepared to conduct more investigations.

Lingua originaleInglese
pagine (da-a)4348-4352
Numero di pagine5
RivistaAdvanced Materials
Volume20
Numero di pubblicazione22
DOI
Stato di pubblicazionePubblicato - 18 nov 2008

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