Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma

Riccardo Moia; Chiara Favini; Valentina Ferri; Gabriela Forestieri; Lodovico Terzi Di Bergamo; Mattia Schipani; Sruthi Sagiraju; Annalisa Andorno; Silvia Rasi; Ramesh Adhinaveni; Donatella Talotta; Wael Al Essa; Lorenzo De Paoli; Gloria Margiotta Casaluci; Andrea Patriarca; Renzo L. Boldorini; Davide Rossi; Gianluca Gaidano

doi:10.1111/bjh.17718

Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma

Riccardo Moia, Chiara Favini, Valentina Ferri, Gabriela Forestieri, Lodovico Terzi Di Bergamo, Mattia Schipani, Sruthi Sagiraju, Annalisa Andorno, Silvia Rasi, Ramesh Adhinaveni, Donatella Talotta, Wael Al Essa, Lorenzo De Paoli, Gloria Margiotta Casaluci, Andrea Patriarca, Renzo L. Boldorini, Davide Rossi, Gianluca Gaidano

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4% and 36·4%, respectively) are unique to each compartment. Plasma ctDNA identified two additional unique mutations. Consistently, the different synchronous sources of tumour DNA complement each other in informing on driver gene mutations in SLL harbouring potential prognostic and/or predictive value.

Lingua originale	Inglese
pagine (da-a)	108-112
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	195
Numero di pubblicazione	1
DOI	https://doi.org/10.1111/bjh.17718
Stato di pubblicazione	Pubblicato - ott 2021

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10.1111/bjh.17718

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Moia, R., Favini, C., Ferri, V., Forestieri, G., Terzi Di Bergamo, L., Schipani, M., Sagiraju, S., Andorno, A., Rasi, S., Adhinaveni, R., Talotta, D., Al Essa, W., De Paoli, L., Margiotta Casaluci, G., Patriarca, A., Boldorini, R. L., Rossi, D., & Gaidano, G. (2021). Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma. British Journal of Haematology, 195(1), 108-112. https://doi.org/10.1111/bjh.17718

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title = "Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma",

abstract = "We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4\% and 36·4\%, respectively) are unique to each compartment. Plasma ctDNA identified two additional unique mutations. Consistently, the different synchronous sources of tumour DNA complement each other in informing on driver gene mutations in SLL harbouring potential prognostic and/or predictive value.",

keywords = "liquid biopsy, multiregional sequencing, small lymphocytic lymphoma",

author = "Riccardo Moia and Chiara Favini and Valentina Ferri and Gabriela Forestieri and \{Terzi Di Bergamo\}, Lodovico and Mattia Schipani and Sruthi Sagiraju and Annalisa Andorno and Silvia Rasi and Ramesh Adhinaveni and Donatella Talotta and \{Al Essa\}, Wael and \{De Paoli\}, Lorenzo and \{Margiotta Casaluci\}, Gloria and Andrea Patriarca and Boldorini, \{Renzo L.\} and Davide Rossi and Gianluca Gaidano",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley \& Sons Ltd.",

year = "2021",

month = oct,

doi = "10.1111/bjh.17718",

language = "English",

volume = "195",

pages = "108--112",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "1",

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Moia, R, Favini, C, Ferri, V, Forestieri, G, Terzi Di Bergamo, L, Schipani, M, Sagiraju, S, Andorno, A, Rasi, S, Adhinaveni, R, Talotta, D, Al Essa, W, De Paoli, L, Margiotta Casaluci, G, Patriarca, A, Boldorini, RL, Rossi, D & Gaidano, G 2021, 'Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma', British Journal of Haematology, vol. 195, n. 1, pagg. 108-112. https://doi.org/10.1111/bjh.17718

Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma. / Moia, Riccardo; Favini, Chiara; Ferri, Valentina et al.
In: British Journal of Haematology, Vol. 195, N. 1, 10.2021, pag. 108-112.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma

AU - Moia, Riccardo

AU - Favini, Chiara

AU - Ferri, Valentina

AU - Forestieri, Gabriela

AU - Terzi Di Bergamo, Lodovico

AU - Schipani, Mattia

AU - Sagiraju, Sruthi

AU - Andorno, Annalisa

AU - Rasi, Silvia

AU - Adhinaveni, Ramesh

AU - Talotta, Donatella

AU - Al Essa, Wael

AU - De Paoli, Lorenzo

AU - Margiotta Casaluci, Gloria

AU - Patriarca, Andrea

AU - Boldorini, Renzo L.

AU - Rossi, Davide

AU - Gaidano, Gianluca

PY - 2021/10

Y1 - 2021/10

N2 - We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4% and 36·4%, respectively) are unique to each compartment. Plasma ctDNA identified two additional unique mutations. Consistently, the different synchronous sources of tumour DNA complement each other in informing on driver gene mutations in SLL harbouring potential prognostic and/or predictive value.

AB - We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort of 12 patients for whom paired DNA from a lymph node biopsy and circulating cells, as well as plasma-circulating tumour DNA (ctDNA) was available. Notably, the analyses of the lymph node biopsy and of circulating cells complement each other since a fraction of mutations (20·4% and 36·4%, respectively) are unique to each compartment. Plasma ctDNA identified two additional unique mutations. Consistently, the different synchronous sources of tumour DNA complement each other in informing on driver gene mutations in SLL harbouring potential prognostic and/or predictive value.

KW - liquid biopsy

KW - multiregional sequencing

KW - small lymphocytic lymphoma

UR - https://www.scopus.com/pages/publications/85110942355

U2 - 10.1111/bjh.17718

DO - 10.1111/bjh.17718

M3 - Article

SN - 0007-1048

VL - 195

SP - 108

EP - 112

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Multiregional sequencing and circulating tumour DNA analysis provide complementary approaches for comprehensive disease profiling of small lymphocytic lymphoma

Abstract

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