Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

Ignazia Prigione; Elio Castagnola; Luisa Imberti; Claudio Gambini; Luigi Gradoni; Umberto Dianzani; Ugo Ramenghi; Francesca Giacopelli; Alessandro Moretta; Lorenzo Moretta; Alessandro Plebani; Alain Fischer; Vito Pistoia

doi:10.1097/INF.0b013e318185513d

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

Ignazia Prigione, Elio Castagnola, Luisa Imberti, Claudio Gambini, Luigi Gradoni, Umberto Dianzani, Ugo Ramenghi, Francesca Giacopelli, Alessandro Moretta, Lorenzo Moretta, Alessandro Plebani, Alain Fischer, Vito Pistoia

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4^-, CD8^- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4⁺ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

Lingua originale	Inglese
pagine (da-a)	161-163
Numero di pagine	3
Rivista	Pediatric Infectious Disease Journal
Volume	28
Numero di pubblicazione	2
DOI	https://doi.org/10.1097/INF.0b013e318185513d
Stato di pubblicazione	Pubblicato - feb 2009

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10.1097/INF.0b013e318185513d

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Prigione, I., Castagnola, E., Imberti, L., Gambini, C., Gradoni, L., Dianzani, U., Ramenghi, U., Giacopelli, F., Moretta, A., Moretta, L., Plebani, A., Fischer, A., & Pistoia, V. (2009). Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features. Pediatric Infectious Disease Journal, 28(2), 161-163. https://doi.org/10.1097/INF.0b013e318185513d

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title = "Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features",

abstract = "An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.",

keywords = "Immune deficiency, Relapsing visceral leishmaniasis",

author = "Ignazia Prigione and Elio Castagnola and Luisa Imberti and Claudio Gambini and Luigi Gradoni and Umberto Dianzani and Ugo Ramenghi and Francesca Giacopelli and Alessandro Moretta and Lorenzo Moretta and Alessandro Plebani and Alain Fischer and Vito Pistoia",

year = "2009",

month = feb,

doi = "10.1097/INF.0b013e318185513d",

language = "English",

volume = "28",

pages = "161--163",

journal = "Pediatric Infectious Disease Journal",

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Prigione, I, Castagnola, E, Imberti, L, Gambini, C, Gradoni, L, Dianzani, U, Ramenghi, U, Giacopelli, F, Moretta, A, Moretta, L, Plebani, A, Fischer, A & Pistoia, V 2009, 'Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features', Pediatric Infectious Disease Journal, vol. 28, n. 2, pagg. 161-163. https://doi.org/10.1097/INF.0b013e318185513d

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features. / Prigione, Ignazia; Castagnola, Elio; Imberti, Luisa et al.
In: Pediatric Infectious Disease Journal, Vol. 28, N. 2, 02.2009, pag. 161-163.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

AU - Prigione, Ignazia

AU - Castagnola, Elio

AU - Imberti, Luisa

AU - Gambini, Claudio

AU - Gradoni, Luigi

AU - Dianzani, Umberto

AU - Ramenghi, Ugo

AU - Giacopelli, Francesca

AU - Moretta, Alessandro

AU - Moretta, Lorenzo

AU - Plebani, Alessandro

AU - Fischer, Alain

AU - Pistoia, Vito

PY - 2009/2

Y1 - 2009/2

N2 - An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

AB - An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

KW - Immune deficiency

KW - Relapsing visceral leishmaniasis

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U2 - 10.1097/INF.0b013e318185513d

DO - 10.1097/INF.0b013e318185513d

M3 - Article

SN - 0891-3668

VL - 28

SP - 161

EP - 163

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 2

ER -

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

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