Multiformalism modeling and simulation of immune system mechanisms

Elvio Gilberto Amparore, Marco Beccuti, Paolo Castagno, Giuliana Franceschinis, Marzio Pennisi, Simone Pernice

Risultato della ricerca: Capitolo in libro/report/atti di convegnoContributo a conferenzapeer review

Abstract

The immune system (IS) represents a complex network of cells and molecules devoted to the protection of individuals from external pathogens, and in terms of complexity, it is only second to the central nervous system. As our knowledge of the IS mechanisms has become more exhaustive, interest has grown in applying modeling and simulation techniques in this context. In particular, among these techniques, the Agent Based Models (ABMs) have been increasingly applied for the IS simulation. One of the major drawbacks of ABMs is represented by the lack of well-defined semantics, which may lead to inconsistent results in comparison to other stochastic approaches. In this paper, we make use of the well-defined semantics and the simulation algorithm for ABMs that we proposed in [1] to implement a few models of the Cancer-Immune System. Comparing ABMs and Gillespie's Stochastic Simulation Algorithm results we show that our methodology brings coherence among the results of ABMs and SSA.

Lingua originaleInglese
Titolo della pubblicazione ospiteProceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
EditorYufei Huang, Lukasz Kurgan, Feng Luo, Xiaohua Tony Hu, Yidong Chen, Edward Dougherty, Andrzej Kloczkowski, Yaohang Li
EditoreInstitute of Electrical and Electronics Engineers Inc.
Pagine3259-3266
Numero di pagine8
ISBN (elettronico)9781665401265
DOI
Stato di pubblicazionePubblicato - 2021
Pubblicato esternamente
Evento2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021 - Virtual, Online, United States
Durata: 9 dic 202112 dic 2021

Serie di pubblicazioni

NomeProceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021

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???event.eventtypes.event.conference???2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021
Paese/TerritorioUnited States
CittàVirtual, Online
Periodo9/12/2112/12/21

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