TY - JOUR
T1 - Multi-cohort study identifies social determinants of systemic inflammation over the life course
AU - Berger, Eloïse
AU - Castagné, Raphaële
AU - Chadeau-Hyam, Marc
AU - Bochud, Murielle
AU - d’Errico, Angelo
AU - Gandini, Martina
AU - Karimi, Maryam
AU - Kivimäki, Mika
AU - Krogh, Vittorio
AU - Marmot, Michael
AU - Panico, Salvatore
AU - Preisig, Martin
AU - Ricceri, Fulvio
AU - Sacerdote, Carlotta
AU - Steptoe, Andrew
AU - Stringhini, Silvia
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Delpierre, Cyrille
AU - Kelly-Irving, Michelle
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. We find a consistent inverse association between SEP and CRP across cohorts, where participants with a less advantaged SEP have higher levels of inflammation. Educational attainment is most strongly related to inflammation, after adjusting for health behaviours, body mass index and later-in-life SEP. These findings suggest socioeconomic disadvantage in young adulthood is independently associated with later life inflammation calling for further studies of the pathways operating through educational processes.
AB - Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. We find a consistent inverse association between SEP and CRP across cohorts, where participants with a less advantaged SEP have higher levels of inflammation. Educational attainment is most strongly related to inflammation, after adjusting for health behaviours, body mass index and later-in-life SEP. These findings suggest socioeconomic disadvantage in young adulthood is independently associated with later life inflammation calling for further studies of the pathways operating through educational processes.
UR - https://www.scopus.com/pages/publications/85061584186
U2 - 10.1038/s41467-019-08732-x
DO - 10.1038/s41467-019-08732-x
M3 - Article
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 773
ER -