MRI nanoprobes based on chemical exchange saturation transfer: Ln III chelates anchored on the surface of mesoporous silica nanoparticles

Giuseppe Ferrauto, Fabio Carniato, Lorenzo Tei, He Hu, Silvio Aime, Mauro Botta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The formation of ternary complexes between neutral LnIII-DO3A chelates anchored on MCM-41 mesoporous silica nanoparticles (MSNs) and silanol groups on the surface allows obtaining highly efficient chemical exchange saturation transfer (CEST) MRI nanoprobes. These new probes achieve excellent sensitivity in the μM range (per LnIII ion), significantly greater than that of other paramagnetic CEST nanosystems such as dendrimers or micelles and three orders of magnitude higher than that of the corresponding molecular agents.

Lingua originaleInglese
pagine (da-a)9604-9607
Numero di pagine4
RivistaNanoscale
Volume6
Numero di pubblicazione16
DOI
Stato di pubblicazionePubblicato - 21 ago 2014

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