Abstract
The formation of ternary complexes between neutral LnIII-DO3A chelates anchored on MCM-41 mesoporous silica nanoparticles (MSNs) and silanol groups on the surface allows obtaining highly efficient chemical exchange saturation transfer (CEST) MRI nanoprobes. These new probes achieve excellent sensitivity in the μM range (per LnIII ion), significantly greater than that of other paramagnetic CEST nanosystems such as dendrimers or micelles and three orders of magnitude higher than that of the corresponding molecular agents.
Lingua originale | Inglese |
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pagine (da-a) | 9604-9607 |
Numero di pagine | 4 |
Rivista | Nanoscale |
Volume | 6 |
Numero di pubblicazione | 16 |
DOI | |
Stato di pubblicazione | Pubblicato - 21 ago 2014 |