Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study

Faiz Ur Rahman; Amjad Ali; Inam Ullah Khan; Muhammad Zeeshan Bhatti; Manuel Petroselli; Hong Quan Duong; Javier Martì-Rujas; Zhan Ting Li; Hui Wang; Dan Wei Zhang

doi:10.1016/j.inoche.2019.02.011

Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study

Faiz Ur Rahman, Amjad Ali, Inam Ullah Khan, Muhammad Zeeshan Bhatti, Manuel Petroselli, Hong Quan Duong, Javier Martì-Rujas, Zhan Ting Li, Hui Wang, Dan Wei Zhang

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)·BF ₄ (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine)) ₂ (4,4-bipyridine)·2BF ₄ (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF ₄ anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.

Lingua originale	Inglese
pagine (da-a)	95-103
Numero di pagine	9
Rivista	Inorganic Chemistry Communication
Volume	102
DOI	https://doi.org/10.1016/j.inoche.2019.02.011
Stato di pubblicazione	Pubblicato - apr 2019
Pubblicato esternamente	Sì

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Rahman, F. U., Ali, A., Khan, I. U., Bhatti, M. Z., Petroselli, M., Duong, H. Q., Martì-Rujas, J., Li, Z. T., Wang, H., & Zhang, D. W. (2019). Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study. Inorganic Chemistry Communication, 102, 95-103. https://doi.org/10.1016/j.inoche.2019.02.011

@article{76ac0aa2b7604639ad872879a709fe61,

title = "Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study",

abstract = " Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)·BF 4 (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine)) 2 (4,4-bipyridine)·2BF 4 (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF 4 anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.",

keywords = "Anticancer effect of Pt(II) complexes, DNA interaction, E. coli growth retardation, Supramolecular Pt(II) complexes",

author = "Rahman, \{Faiz Ur\} and Amjad Ali and Khan, \{Inam Ullah\} and Bhatti, \{Muhammad Zeeshan\} and Manuel Petroselli and Duong, \{Hong Quan\} and Javier Mart{\`i}-Rujas and Li, \{Zhan Ting\} and Hui Wang and Zhang, \{Dan Wei\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = apr,

doi = "10.1016/j.inoche.2019.02.011",

language = "English",

volume = "102",

pages = "95--103",

journal = "Inorganic Chemistry Communication",

issn = "1387-7003",

publisher = "Elsevier BV",

}

Rahman, FU, Ali, A, Khan, IU, Bhatti, MZ, Petroselli, M, Duong, HQ, Martì-Rujas, J, Li, ZT, Wang, H & Zhang, DW 2019, 'Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study', Inorganic Chemistry Communication, vol. 102, pagg. 95-103. https://doi.org/10.1016/j.inoche.2019.02.011

Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study. / Rahman, Faiz Ur; Ali, Amjad; Khan, Inam Ullah et al.
In: Inorganic Chemistry Communication, Vol. 102, 04.2019, pag. 95-103.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Monofunctional supramolecular Pt(II) complexes

T2 - Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study

AU - Rahman, Faiz Ur

AU - Ali, Amjad

AU - Khan, Inam Ullah

AU - Bhatti, Muhammad Zeeshan

AU - Petroselli, Manuel

AU - Duong, Hong Quan

AU - Martì-Rujas, Javier

AU - Li, Zhan Ting

AU - Wang, Hui

AU - Zhang, Dan Wei

PY - 2019/4

Y1 - 2019/4

N2 - Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)·BF 4 (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine)) 2 (4,4-bipyridine)·2BF 4 (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF 4 anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.

AB - Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)·BF 4 (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine)) 2 (4,4-bipyridine)·2BF 4 (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF 4 anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.

KW - Anticancer effect of Pt(II) complexes

KW - DNA interaction

KW - E. coli growth retardation

KW - Supramolecular Pt(II) complexes

UR - https://www.scopus.com/pages/publications/85061696663

U2 - 10.1016/j.inoche.2019.02.011

DO - 10.1016/j.inoche.2019.02.011

M3 - Article

SN - 1387-7003

VL - 102

SP - 95

EP - 103

JO - Inorganic Chemistry Communication

JF - Inorganic Chemistry Communication

ER -

Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study

Abstract

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