MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT

BILOUS NI; R BOMBEN; BO M DAL; Daniela CAPELLO; F FORCONI; L LAURENTI; F BERTONI; EFREMOV DG; R MARASCA; POETA G DEL; Z MARTINA; I KRYACHOUK; I DYAGIL; Gianluca GAIDANO; A CHUMAK; V GATTEI; I. ABRAMENKO

doi:10.3109/10428191003646002

MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT

BILOUS NI, R BOMBEN, BO M DAL, Daniela CAPELLO, F FORCONI, L LAURENTI, F BERTONI, EFREMOV DG, R MARASCA, POETA G DEL, Z MARTINA, I KRYACHOUK, I DYAGIL, Gianluca GAIDANO, A CHUMAK, V GATTEI, I. ABRAMENKO

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.

Lingua originale	Inglese
pagine (da-a)	822-838
Numero di pagine	17
Rivista	LEUKEMIA & LYMPHOMA
Volume	51
Numero di pubblicazione	5
DOI	https://doi.org/10.3109/10428191003646002
Stato di pubblicazione	Pubblicato - 2010

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NI, BILOUS., BOMBEN, R., DAL, BO. M., CAPELLO, D., FORCONI, F., LAURENTI, L., BERTONI, F., DG, EFREMOV., MARASCA, R., DEL, POETA. G., MARTINA, Z., KRYACHOUK, I., DYAGIL, I., GAIDANO, G., CHUMAK, A., GATTEI, V., & ABRAMENKO, I. (2010). MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT. LEUKEMIA & LYMPHOMA, 51(5), 822-838. https://doi.org/10.3109/10428191003646002

@article{a23fa4ab1cae48a0ae890f08ab7d1b6f,

title = "MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT",

abstract = "A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.",

author = "BILOUS NI and R BOMBEN and DAL, {BO M} and Daniela CAPELLO and F FORCONI and L LAURENTI and F BERTONI and EFREMOV DG and R MARASCA and DEL, {POETA G} and Z MARTINA and I KRYACHOUK and I DYAGIL and Gianluca GAIDANO and A CHUMAK and V GATTEI and I. ABRAMENKO",

note = "Funding Information: Declaration of interest: This study was supported in part by: Ministero della Salute (Ricerca Finalizzata I.R.C.C.S. and {\textquoteleft}Alleanza Contro il Cancro{\textquoteright}), Rome, Italy; Associazione Italiana contro le Leucemie, linfomi e mielomi (A.I.L.), Venezia Section, Pra-maggiore Group, Italy; Ricerca Scientifica Applicata, Regione Friuli Venezia Giulia, Trieste ({\textquoteleft}Linfonet{\textquoteright}), Italy; Programmi di Ricerca di Interesse Nazionale (P.R.I.N.) and Fondo per gli Investimenti per la Ricerca di Base (F.I.R.B.), M.U.R., Rome, Italy; Novara-A.I.L. Onlus, Novara, Italy; Ricerca Sanitaria Finalizzata Regione Piemonte, Torino, Italy; Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.), Milan, Italy; Piano di Ateneo per la Ricerca (P.A.R.) 2005, University of Siena, Italy; Hairy Cell Leukemia Research Foundation (Illinois, USA); Helmut Horten Foundation (Lugano, Switzerland); San Salvatore Foundation (Lugano, Switzerland); Fondazione per la Ricerca e la Cura sui Linfomi (Lugano, Switzerland); KIHEV Kinderhilfe Kiew e.V. (Weil am Rhein, Germany).",

year = "2010",

doi = "10.3109/10428191003646002",

language = "English",

volume = "51",

pages = "822--838",

journal = "LEUKEMIA & LYMPHOMA",

issn = "1042-8194",

number = "5",

}

NI, BILOUS, BOMBEN, R, DAL, BOM, CAPELLO, D, FORCONI, F, LAURENTI, L, BERTONI, F, DG, EFREMOV, MARASCA, R, DEL, POETAG, MARTINA, Z, KRYACHOUK, I, DYAGIL, I, GAIDANO, G, CHUMAK, A, GATTEI, V & ABRAMENKO, I 2010, 'MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT', LEUKEMIA & LYMPHOMA, vol. 51, n. 5, pagg. 822-838. https://doi.org/10.3109/10428191003646002

TY - JOUR

T1 - MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT

AU - NI, BILOUS

AU - BOMBEN, R

AU - DAL, BO M

AU - CAPELLO, Daniela

AU - FORCONI, F

AU - LAURENTI, L

AU - BERTONI, F

AU - DG, EFREMOV

AU - MARASCA, R

AU - DEL, POETA G

AU - MARTINA, Z

AU - KRYACHOUK, I

AU - DYAGIL, I

AU - GAIDANO, Gianluca

AU - CHUMAK, A

AU - GATTEI, V

AU - ABRAMENKO, I.

N1 - Funding Information: Declaration of interest: This study was supported in part by: Ministero della Salute (Ricerca Finalizzata I.R.C.C.S. and ‘Alleanza Contro il Cancro’), Rome, Italy; Associazione Italiana contro le Leucemie, linfomi e mielomi (A.I.L.), Venezia Section, Pra-maggiore Group, Italy; Ricerca Scientifica Applicata, Regione Friuli Venezia Giulia, Trieste (‘Linfonet’), Italy; Programmi di Ricerca di Interesse Nazionale (P.R.I.N.) and Fondo per gli Investimenti per la Ricerca di Base (F.I.R.B.), M.U.R., Rome, Italy; Novara-A.I.L. Onlus, Novara, Italy; Ricerca Sanitaria Finalizzata Regione Piemonte, Torino, Italy; Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.), Milan, Italy; Piano di Ateneo per la Ricerca (P.A.R.) 2005, University of Siena, Italy; Hairy Cell Leukemia Research Foundation (Illinois, USA); Helmut Horten Foundation (Lugano, Switzerland); San Salvatore Foundation (Lugano, Switzerland); Fondazione per la Ricerca e la Cura sui Linfomi (Lugano, Switzerland); KIHEV Kinderhilfe Kiew e.V. (Weil am Rhein, Germany).

PY - 2010

Y1 - 2010

N2 - A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.

AB - A fraction of chronic lymphocytic leukemia (CLL) carries highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity-determining region-3 (HCDR3), often associated with a restricted selection of IG(K/L)V light chains. We analyzed the features of CLL expressing homologous HCDR3 in a cohort of 264 Ukrainian patients by merging them with a recently published reference series of 1426 cases. This approach allowed us to identify 96/264 (36%) cases as expressing homologous HCDR3, subdivided into 47 subsets. Among these, 27 apparently novel subsets were identified, although most of them were composed of two sequences per subset ('potential subsets'). CLL cases belonging to several stereotyped subsets showed HCDR3 homologies with various autoreactive clones. Our analysis identified molecular and clinical features of a Ukrainian cohort of patients with CLL.

UR - https://iris.uniupo.it/handle/11579/24677

U2 - 10.3109/10428191003646002

DO - 10.3109/10428191003646002

M3 - Article

SN - 1042-8194

VL - 51

SP - 822

EP - 838

JO - LEUKEMIA & LYMPHOMA

JF - LEUKEMIA & LYMPHOMA

IS - 5

ER -

MOLECULAR AND CLINICAL FEATURES OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH STEREOTYPED B-CELL RECEPTORS IN A UKRAINIAN COHORT

Abstract

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