Mimosine induces apoptosis in the HL60 human tumor cell line

F. Renó; A. Tontini; S. Burattini; S. Papa; E. Falcieri; G. Tarzia

doi:10.1023/A:1009608628076

Mimosine induces apoptosis in the HL60 human tumor cell line

F. Renó, A. Tontini, S. Burattini, S. Papa, E. Falcieri, G. Tarzia

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line- specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.

Lingua originale	Inglese
pagine (da-a)	469-477
Numero di pagine	9
Rivista	Apoptosis : an international journal on programmed cell death
Volume	4
Numero di pubblicazione	6
DOI	https://doi.org/10.1023/A:1009608628076
Stato di pubblicazione	Pubblicato - 1999

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title = "Mimosine induces apoptosis in the HL60 human tumor cell line",

abstract = "Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line- specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.",

keywords = "Apoptosis, Cell cycle synchronization, HL60, Hypusine, K562, Mimosine",

author = "F. Ren{\'o} and A. Tontini and S. Burattini and S. Papa and E. Falcieri and G. Tarzia",

note = "Funding Information: This research was funded by a grant from the C.N.R. (Italian National Research Council) (No. 9603134.04), by MURST (Italian Ministry for University and for Scientific and Technological Research) and by the Faculty of Pharmacy of the University of Urbino (Italy).",

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doi = "10.1023/A:1009608628076",

language = "English",

volume = "4",

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journal = "Apoptosis : an international journal on programmed cell death",

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TY - JOUR

T1 - Mimosine induces apoptosis in the HL60 human tumor cell line

AU - Renó, F.

AU - Tontini, A.

AU - Burattini, S.

AU - Papa, S.

AU - Falcieri, E.

AU - Tarzia, G.

N1 - Funding Information: This research was funded by a grant from the C.N.R. (Italian National Research Council) (No. 9603134.04), by MURST (Italian Ministry for University and for Scientific and Technological Research) and by the Faculty of Pharmacy of the University of Urbino (Italy).

PY - 1999

Y1 - 1999

N2 - Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line- specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.

AB - Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line- specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.

KW - Apoptosis

KW - Cell cycle synchronization

KW - HL60

KW - Hypusine

KW - K562

KW - Mimosine

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U2 - 10.1023/A:1009608628076

DO - 10.1023/A:1009608628076

M3 - Article

SN - 1360-8185

VL - 4

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EP - 477

JO - Apoptosis : an international journal on programmed cell death

JF - Apoptosis : an international journal on programmed cell death

IS - 6

ER -

Mimosine induces apoptosis in the HL60 human tumor cell line

Abstract

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