Milk fat globule membrane components-a proteomic approach

Maria Cavaletto, Maria Gabriella Giuffrida, Amedeo Conti

Risultato della ricerca: Capitolo in libro/report/atti di convegnoContributo in volume (Capitolo o Saggio)peer review

Abstract

The milk fat globule membrane (MFGM) is the membrane surrounding lipid droplets during their secretion in the alveolar lumen of the lactating mammary gland. MFGM proteins represent only 1-4% of total milk protein content; nevertheless, the MFGM consists of a complex system of integral and peripheral proteins, enzymes, and lipids. Despite their low classical nutritional value, MFGMproteins have been reported to play an important role in various cellular processes and defense mechanisms in the newborn. Using a proteomic approach, such as high-resolution, two-dimensional electrophoresis followed by direct protein identification by mass spectrometry, it has been possible to comprehensively characterize the subcellular organization of MFGM. This chapter covers the description of MFGM proteomics from the first studies about 10 years ago through the most recent papers. Most of the investigations deal with MFGMs from human and cow milk.

Lingua originaleInglese
Titolo della pubblicazione ospiteBioactive Components of Milk
EditoreSpringer New York
Pagine129-141
Numero di pagine13
ISBN (stampa)9780387740867
DOI
Stato di pubblicazionePubblicato - 2008

Serie di pubblicazioni

NomeAdvances in Experimental Medicine and Biology
Volume606
ISSN (stampa)0065-2598

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