Abstract
Aziridine derivatives involved in nucleophilic ring-opening reactions have attracted great interest, since they allow the preparation of biologically active molecules. A chemoselective and mild procedure to convert a peptide cysteine residue into lanthionine via S-alkylation on aziridine substrates is presented in this paper. The procedure relies on a post-synthetic protocol promoted by molecular sieves to prepare lanthionine-containing peptides and is assisted by microwave irradiation. In addition, it represents a valuable alternative to the stepwise approach, in which the lanthionine precursor is incorporated into peptides as a building block.
Lingua originale | Inglese |
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Numero di articolo | 6135 |
Rivista | Molecules |
Volume | 26 |
Numero di pubblicazione | 20 |
DOI | |
Stato di pubblicazione | Pubblicato - 2 ott 2021 |