MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

Elisa Penna; Francesca Orso; Daniela Cimino; Enrico Tenaglia; Antonio Lembo; Elena Quaglino; Laura Poliseno; Adele Haimovic; Simona Osella-Abate; Cristiano De Pittá; Eva Pinatel; Michael B. Stadler; Paolo Provero; Maria Grazia Bernengo; Iman Osman; Daniela Taverna

doi:10.1038/emboj.2011.102

MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

Elisa Penna, Francesca Orso, Daniela Cimino, Enrico Tenaglia, Antonio Lembo, Elena Quaglino, Laura Poliseno, Adele Haimovic, Simona Osella-Abate, Cristiano De Pittá, Eva Pinatel, Michael B. Stadler, Paolo Provero, Maria Grazia Bernengo, Iman Osman, Daniela Taverna

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.

Lingua originale	Inglese
pagine (da-a)	1990-2007
Numero di pagine	18
Rivista	EMBO Journal
Volume	30
Numero di pubblicazione	10
DOI	https://doi.org/10.1038/emboj.2011.102
Stato di pubblicazione	Pubblicato - 18 mag 2011
Pubblicato esternamente	Sì

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Penna, E., Orso, F., Cimino, D., Tenaglia, E., Lembo, A., Quaglino, E., Poliseno, L., Haimovic, A., Osella-Abate, S., De Pittá, C., Pinatel, E., Stadler, M. B., Provero, P., Bernengo, M. G., Osman, I., & Taverna, D. (2011). MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO Journal, 30(10), 1990-2007. https://doi.org/10.1038/emboj.2011.102

@article{52600c52c2ad41c2a59cbdd7149f694f,

title = "MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C",

abstract = "Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.",

keywords = "TFAP2C, extravasation, melanoma, miR-214, tumour progression",

author = "Elisa Penna and Francesca Orso and Daniela Cimino and Enrico Tenaglia and Antonio Lembo and Elena Quaglino and Laura Poliseno and Adele Haimovic and Simona Osella-Abate and {De Pitt{\'a}}, Cristiano and Eva Pinatel and Stadler, {Michael B.} and Paolo Provero and Bernengo, {Maria Grazia} and Iman Osman and Daniela Taverna",

year = "2011",

month = may,

day = "18",

doi = "10.1038/emboj.2011.102",

language = "English",

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journal = "EMBO Journal",

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Penna, E, Orso, F, Cimino, D, Tenaglia, E, Lembo, A, Quaglino, E, Poliseno, L, Haimovic, A, Osella-Abate, S, De Pittá, C, Pinatel, E, Stadler, MB, Provero, P, Bernengo, MG, Osman, I & Taverna, D 2011, 'MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C', EMBO Journal, vol. 30, n. 10, pagg. 1990-2007. https://doi.org/10.1038/emboj.2011.102

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T1 - MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

AU - Penna, Elisa

AU - Orso, Francesca

AU - Cimino, Daniela

AU - Tenaglia, Enrico

AU - Lembo, Antonio

AU - Quaglino, Elena

AU - Poliseno, Laura

AU - Haimovic, Adele

AU - Osella-Abate, Simona

AU - De Pittá, Cristiano

AU - Pinatel, Eva

AU - Stadler, Michael B.

AU - Provero, Paolo

AU - Bernengo, Maria Grazia

AU - Osman, Iman

AU - Taverna, Daniela

PY - 2011/5/18

Y1 - 2011/5/18

N2 - Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.

AB - Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.

KW - TFAP2C

KW - extravasation

KW - melanoma

KW - miR-214

KW - tumour progression

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U2 - 10.1038/emboj.2011.102

DO - 10.1038/emboj.2011.102

M3 - Article

SN - 0261-4189

VL - 30

SP - 1990

EP - 2007

JO - EMBO Journal

JF - EMBO Journal

IS - 10

ER -

MicroRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

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