@article{d87b60dbcdc1475b9dbd9d67f18fe9db,
title = "Methods for Synthesizing Findings on Moderation Effects Across Multiple Randomized Trials",
abstract = "This paper presents new methods for synthesizing results from subgroup and moderation analyses across different randomized trials. We demonstrate that such a synthesis generally results in additional power to detect significant moderation findings above what one would find in a single trial. Three general methods for conducting synthesis analyses are discussed, with two methods, integrative data analysis and parallel analyses, sharing a large advantage over traditional methods available in meta-analysis. We present a broad class of analytic models to examine moderation effects across trials that can be used to assess their overall effect and explain sources of heterogeneity, and present ways to disentangle differences across trials due to individual differences, contextual level differences, intervention, and trial design.",
keywords = "Integrative data analysis, Meta-analysis, Parallel data analysis, Subgroup analyses, Variation in impact",
author = "Brown, {C. Hendricks} and Zili Sloboda and Fabrizio Faggiano and Brent Teasdale and Ferdinand Keller and Gregor Burkhart and Federica Vigna-Taglianti and George Howe and Katherine Masyn and Wei Wang and Bengt Muth{\'e}n and Peggy Stephens and Scott Grey and Tatiana Perrino",
note = "Funding Information: Acknowledgements We would like to thank our colleagues in the Prevention Science and Methodology Group (PSMG) for their suggestions in the development of this paper. This project was funded by a National Institute on Drug Abuse supplement to the Prevention Science and Methodology Group for the US-EU Drug Abuse Prevention Project (R01MH040859; Brown, Sloboda, Muth{\'e}n, Masyn, Wang), Robert Wood Johnson Foundation (No. 039223, 040371) for Sloboda, Stephens, Grey, Teasdale. The EU-Drug Abuse Prevention Project is funded by the European Commission (European Public Health programme 2002 grant # SPC 2002376, Faggiano, Vigna-Taglianti), and the parallel data analyses supported by the European Monitoring Centre for Drugs and Drug Addiction (Burkhart, CT.09.RES.005.1.0: Keller). We would also like to thank J G Perpich LLC for their support in the use of the NIDA International Virtual Collaboratory funded through N44DA000000-00409, for their logistical support in developing our international collaboration. A version of this paper was presented by the first author at the “Foundational Issues in Examining Subgroup Effects in Experiments” Interagency Federal Methodological Meeting: Subgroup Analysis in Prevention and Intervention Research, Washington, DC.",
year = "2013",
month = apr,
doi = "10.1007/s11121-011-0207-8",
language = "English",
volume = "14",
pages = "144--156",
journal = "Prevention Science",
issn = "1389-4986",
publisher = "Springer New York",
number = "2",
}
