Abstract
Plasma cell-free DNA (cfDNA) is an easily accessible source of tumor DNA that allows accurate profiling of lymphoma patients, representing a complementary source of tumor DNA to tissue biopsy for genotyping. Applications of cfDNA analysis in lymphomas include: (1) identification of tumor mutations in a biopsy-free manner; (2) tracking tumor clonal evolution and identification of mutations causing resistance to treatment; and (3) monitoring of residual disease after therapy.
Lingua originale | Inglese |
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Titolo della pubblicazione ospite | Methods in molecular biology |
Pagine | 253-265 |
Numero di pagine | 13 |
Volume | 1881 |
DOI | |
Stato di pubblicazione | Pubblicato - 2019 |
Keywords
- Genetics
- Genotyping
- Liquid biopsy
- Lymphomas
- Molecular Biology
- Next-generation sequencing
- cfDNA