Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes

O. Caputo; F. Rocco; G. Grosa

doi:10.1007/BF03188856

Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes

O. Caputo, F. Rocco, G. Grosa

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.

Lingua originale	Inglese
pagine (da-a)	303-310
Numero di pagine	8
Rivista	European Journal of Drug Metabolism and Pharmacokinetics
Volume	19
Numero di pubblicazione	4
DOI	https://doi.org/10.1007/BF03188856
Stato di pubblicazione	Pubblicato - dic 1994
Pubblicato esternamente	Sì

Accesso al documento

10.1007/BF03188856

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{da33a123ac934618b85fc8327b4cc932,

title = "Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes",

abstract = "The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.",

keywords = "4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine, D-16120, drug metabolism",

author = "O. Caputo and F. Rocco and G. Grosa",

year = "1994",

month = dec,

doi = "10.1007/BF03188856",

language = "English",

volume = "19",

pages = "303--310",

journal = "European Journal of Drug Metabolism and Pharmacokinetics",

issn = "0378-7966",

publisher = "Adis",

number = "4",

}

TY - JOUR

T1 - Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes

AU - Caputo, O.

AU - Rocco, F.

AU - Grosa, G.

PY - 1994/12

Y1 - 1994/12

N2 - The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.

AB - The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.

KW - 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine

KW - D-16120

KW - drug metabolism

UR - http://www.scopus.com/inward/record.url?scp=0028569491&partnerID=8YFLogxK

U2 - 10.1007/BF03188856

DO - 10.1007/BF03188856

M3 - Article

SN - 0378-7966

VL - 19

SP - 303

EP - 310

JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 4

ER -

Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo