Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes

O. Caputo; G. Grosa; M. Ceruti; F. Rocco; G. Biglino

Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes

O. Caputo
, G. Grosa
, M. Ceruti
, F. Rocco
, G. Biglino

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The metabolic fate of the anti-estrogen 1,1,-dichloro-cis-diphenylcyclopropane (Analog II), was studied in vitro with phenobarbital-induced rat liver microsomal fractions. The presence of five metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The presence of an allyl chloride, highly reactive, metabolic intermediate was stated.

Lingua originale	Inglese
pagine (da-a)	771-778
Numero di pagine	8
Rivista	Drug Metabolism and Disposition
Volume	18
Numero di pubblicazione	5
Stato di pubblicazione	Pubblicato - 1990
Pubblicato esternamente	Sì

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title = "Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes",

abstract = "The metabolic fate of the anti-estrogen 1,1,-dichloro-cis-diphenylcyclopropane (Analog II), was studied in vitro with phenobarbital-induced rat liver microsomal fractions. The presence of five metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The presence of an allyl chloride, highly reactive, metabolic intermediate was stated.",

author = "O. Caputo and G. Grosa and M. Ceruti and F. Rocco and G. Biglino",

year = "1990",

language = "English",

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journal = "Drug Metabolism and Disposition",

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T1 - Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes

AU - Caputo, O.

AU - Grosa, G.

AU - Ceruti, M.

AU - Rocco, F.

AU - Biglino, G.

PY - 1990

Y1 - 1990

N2 - The metabolic fate of the anti-estrogen 1,1,-dichloro-cis-diphenylcyclopropane (Analog II), was studied in vitro with phenobarbital-induced rat liver microsomal fractions. The presence of five metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The presence of an allyl chloride, highly reactive, metabolic intermediate was stated.

AB - The metabolic fate of the anti-estrogen 1,1,-dichloro-cis-diphenylcyclopropane (Analog II), was studied in vitro with phenobarbital-induced rat liver microsomal fractions. The presence of five metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The presence of an allyl chloride, highly reactive, metabolic intermediate was stated.

UR - https://www.scopus.com/pages/publications/0025165529

M3 - Article

SN - 0090-9556

VL - 18

SP - 771

EP - 778

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

IS - 5

ER -

Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes

Abstract

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