@article{b830fbab44ef4eec8791afc9d483a7a6,
title = "Meta and pooled analysis of European coeliac disease data",
abstract = "Four full genome scans have been carried out by the partners of the European cluster on coeliac disease as well as follow-up studies of candidate regions. No region outside HLA showed significant linkage to the disease in any single study. We first applied a meta-analysis based on a modification of Genome Screen Meta-Analysis to take into account the different linkage statistics, the arbitrariness of bin cutoff points, as well as the sample size of each study. We then performed a pooled linkage analysis of all families and raw genotypes. Besides the HLA region, already known to harbour a risk factor for coeliac disease, both approaches leave very little doubt on the presence of a genetic risk factor in the 5q31-33 region. This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately.",
keywords = "Coeliac disease, GSMA, Genome scan, Mega-analysis, Meta-analysis, Pooled analysis",
author = "Babron, \{Marie Claude\} and Staffan Nilsson and Svetlana Adamovic and Naluai, \{{\AA}sa Torinsson\} and Jan Wahlstr{\"o}m and Henry Ascher and Ciclitira, \{Paul J.\} and Sollid, \{Ludvig M.\} and Jukka Partanen and Luigi Greco and Fran{\c c}oise Clerget-Darpoux and P. Holopainen and K. Karell and P. Collin and K. Mustalahti and M. M{\"a}ki and F. Clot and Hugot, \{J. P.\} and S. D'Alfonso and E. Bolognesi and M. Giordano and M. Mellai and P. Momigliano-Richiardi and I. Coto and S. Percopo and R. Tosi and Louka, \{A. S.\} and B. Talseth and J. Ek and Gudj{\'o}nsd{\'o}ttir, \{A. H.\} and B. Kristiansson and T. Martinsson and L. Samuelsson and Olle Nerman and J. Fraser and A. King and Moodie, \{S. J.\}",
note = "Funding Information: This study was funded by the Commission of the European Communities, RTD programme {\textquoteleft}Quality of Life and Management of Living Resources{\textquoteright} (QLKT-1999-00037), {\textquoteleft}Evaluation of the prevalence of coeliac disease and its genetic components in the European population{\textquoteright}. This paper does not necessarily reflect its views and in no way anticipates the Commission{\textquoteright}s future policy in this area. Grants for the study were also given by The Swedish Medical Research Council, Wilhelm and Martina Lundgren{\textquoteright}s Research Foundation, The Swedish Medical Society, the Swedish Coeliac Society, the Sigrid Juselius Foundation, the Medical Research Funds of Finnish Red Cross Blood Transfusion Service, the University of Helsinki, Emil Aaltonen Foundation, Maud Kuistila Memorial Foundation, P{\"a}ivikki and Sakari Sohlberg Foundation, Foundation of the Friends of the University Children{\textquoteright}s Hospitals in Finland, Academy of Finland Research Council for Health (decision 73489), and the Medical Research Fund of Tampere University Hospital.",
year = "2003",
month = nov,
day = "1",
doi = "10.1038/sj.ejhg.5201051",
language = "English",
volume = "11",
pages = "828--834",
journal = "European Journal of Human Genetics",
issn = "1018-4813",
publisher = "Springer Nature",
number = "11",
}