TY - JOUR
T1 - Mesoporous silica nanoparticles-based nanoplatforms for photodynamic therapy
AU - Miletto, Ivana
AU - Gianotti, Enrica
AU - Estevão, Bianca Martins
AU - Marchese, Leonardo
N1 - Publisher Copyright:
© 2017 American Scientific Publishers All rights reserved.
PY - 2017
Y1 - 2017
N2 - Highly efficient nanoplatforms for photodynamic therapy were obtained by covalent conjugation of verteporfin (Ver) and Rose Bengal (RB) within mesoporous silica nanoparticles. Hosting of the photosensitizers (PS) into mesoporous silica nanoparticles allowed overcoming their specific limitations, such as hydrophobicity of Ver, which causes its aggregation in aqueous media, and hydrophilicity of RB, which limits their uptake by target cells. PS loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatforms are able to largely reduce the proliferation of different cell lines, including in the high malignancy melanoma cellular model (SK-MEL-28).
AB - Highly efficient nanoplatforms for photodynamic therapy were obtained by covalent conjugation of verteporfin (Ver) and Rose Bengal (RB) within mesoporous silica nanoparticles. Hosting of the photosensitizers (PS) into mesoporous silica nanoparticles allowed overcoming their specific limitations, such as hydrophobicity of Ver, which causes its aggregation in aqueous media, and hydrophilicity of RB, which limits their uptake by target cells. PS loading, dispersion and efficiency in the photoproduction and delivery of singlet oxygen (1O2) were carefully evaluated. In vitro tests have evidenced that the optimized nanoplatforms are able to largely reduce the proliferation of different cell lines, including in the high malignancy melanoma cellular model (SK-MEL-28).
KW - Mesoporous silica nanoparticles
KW - Photodynamic therapy
KW - Rose bengal
KW - Singlet oxygen delivery
KW - Verteporfin
UR - http://www.scopus.com/inward/record.url?scp=85027860926&partnerID=8YFLogxK
U2 - 10.1166/asl.2017.9044
DO - 10.1166/asl.2017.9044
M3 - Article
SN - 1936-6612
VL - 23
SP - 5837
EP - 5840
JO - Advanced Science Letters
JF - Advanced Science Letters
IS - 6
ER -