TY - JOUR
T1 - Mesenchymal stem/stromal cells
T2 - A new "cells as drugs" paradigm. efficacy and critical aspects in cell therapy
AU - de Girolamo, Laura
AU - Lucarelli, Enrico
AU - Alessandri, Giulio
AU - Avanzini, Maria Antonietta
AU - Bernardo, Maria Ester
AU - Biagi, Ettore
AU - Brini, Anna Teresa
AU - D'Amico, Giovanna
AU - Fagioli, Franca
AU - Ferrero, Ivana
AU - Locatelli, Franco
AU - Maccario, Rita
AU - Marazzi, Mario
AU - Parolini, Ornella
AU - Pessina, Augusto
AU - Torre, Maria Luisa
PY - 2013
Y1 - 2013
N2 - Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
AB - Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
KW - Advanced therapy medicinal product
KW - Cell therapy
KW - Graft versus host disease
KW - Immunomodulatory properties
KW - MSCs sources
KW - Mesenchymal stem/stromal cells
KW - Regenerative medicine
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=84877820900&partnerID=8YFLogxK
U2 - 10.2174/1381612811319130015
DO - 10.2174/1381612811319130015
M3 - Article
SN - 1381-6128
VL - 19
SP - 2459
EP - 2473
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 13
ER -