Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica; Augusto Bleve; Marina Chiara Garassino

doi:10.1016/j.cmet.2019.05.011

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica
, Augusto Bleve
, Marina Chiara Garassino

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Breve indagine › peer review

Abstract

The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

Lingua originale	Inglese
pagine (da-a)	1238-1240
Numero di pagine	3
Rivista	Cell Metabolism
Volume	29
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.cmet.2019.05.011
Stato di pubblicazione	Pubblicato - 4 giu 2019

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SDG 3 Salute e benessere

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10.1016/j.cmet.2019.05.011

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@article{6c649147df594197a7171371d79a660b,

title = "Membrane Cholesterol Regulates Macrophage Plasticity in Cancer",

abstract = "The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.",

author = "Antonio Sica and Augusto Bleve and Garassino, \{Marina Chiara\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jun,

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doi = "10.1016/j.cmet.2019.05.011",

language = "English",

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T1 - Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

AU - Sica, Antonio

AU - Bleve, Augusto

AU - Garassino, Marina Chiara

PY - 2019/6/4

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N2 - The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

AB - The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

UR - https://www.scopus.com/pages/publications/85066282834

U2 - 10.1016/j.cmet.2019.05.011

DO - 10.1016/j.cmet.2019.05.011

M3 - Short survey

SN - 1550-4131

VL - 29

SP - 1238

EP - 1240

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Abstract

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