Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica; Augusto Bleve; Marina Chiara Garassino

doi:10.1016/j.cmet.2019.05.011

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Antonio Sica, Augusto Bleve, Marina Chiara Garassino

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Breve indagine › peer review

Abstract

The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

Lingua originale	Inglese
pagine (da-a)	1238-1240
Numero di pagine	3
Rivista	Cell Metabolism
Volume	29
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.cmet.2019.05.011
Stato di pubblicazione	Pubblicato - 4 giu 2019

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title = "Membrane Cholesterol Regulates Macrophage Plasticity in Cancer",

abstract = "The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.",

author = "Antonio Sica and Augusto Bleve and Garassino, {Marina Chiara}",

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year = "2019",

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T1 - Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

AU - Sica, Antonio

AU - Bleve, Augusto

AU - Garassino, Marina Chiara

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N2 - The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

AB - The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

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DO - 10.1016/j.cmet.2019.05.011

M3 - Short survey

SN - 1550-4131

VL - 29

SP - 1238

EP - 1240

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

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Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Abstract

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