Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain

Suzanne Denis-Donini, Andrea Caprini, Carolina Frassoni, Mariagrazia Grilli

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The Rel/NF-κB family of transcription factors is implicated in cell proliferation, cell death, cell migration and cell interactions. Here, we examined by immunohistochemistry the expression pattern of various members of this family during postnatal telencephalon development and during adulthood, and we used neuronal and glial markers to identify the cells types where they are expressed. Distinct Rel/NF-κB proteins are highly expressed postnatally in the subventricular zone and in the rostral migratory stream. In particular, Rel A and p50 are expressed in radial glial cells, in migrating neuron precursors and in a population belonging to the astrocytic lineage. Rel B, on the other hand, is only expressed in migrating neuron precursors, whereas c-Rel is present in a few cells located at the edges of the rostral migratory stream. The expression of Rel A and p50 persists into adulthood, particularly in subventricular zone astrocyte-like cells and in migrating neuron precursors, respectively. The selective expression of NF-κB members in the postnatal subventricular zone and rostral migratory stream and their persistence into adulthood in regions of ongoing neurogenesis suggests possible mechanisms linking NF-κB expression with cell proliferation and migration. Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-κB may be part of a signaling pathway that is important for neurogenesis.

Lingua originaleInglese
pagine (da-a)81-89
Numero di pagine9
RivistaDevelopmental Brain Research
Volume154
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 1 gen 2005
Pubblicato esternamente

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