TY - JOUR
T1 - Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain
AU - Denis-Donini, Suzanne
AU - Caprini, Andrea
AU - Frassoni, Carolina
AU - Grilli, Mariagrazia
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The Rel/NF-κB family of transcription factors is implicated in cell proliferation, cell death, cell migration and cell interactions. Here, we examined by immunohistochemistry the expression pattern of various members of this family during postnatal telencephalon development and during adulthood, and we used neuronal and glial markers to identify the cells types where they are expressed. Distinct Rel/NF-κB proteins are highly expressed postnatally in the subventricular zone and in the rostral migratory stream. In particular, Rel A and p50 are expressed in radial glial cells, in migrating neuron precursors and in a population belonging to the astrocytic lineage. Rel B, on the other hand, is only expressed in migrating neuron precursors, whereas c-Rel is present in a few cells located at the edges of the rostral migratory stream. The expression of Rel A and p50 persists into adulthood, particularly in subventricular zone astrocyte-like cells and in migrating neuron precursors, respectively. The selective expression of NF-κB members in the postnatal subventricular zone and rostral migratory stream and their persistence into adulthood in regions of ongoing neurogenesis suggests possible mechanisms linking NF-κB expression with cell proliferation and migration. Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-κB may be part of a signaling pathway that is important for neurogenesis.
AB - The Rel/NF-κB family of transcription factors is implicated in cell proliferation, cell death, cell migration and cell interactions. Here, we examined by immunohistochemistry the expression pattern of various members of this family during postnatal telencephalon development and during adulthood, and we used neuronal and glial markers to identify the cells types where they are expressed. Distinct Rel/NF-κB proteins are highly expressed postnatally in the subventricular zone and in the rostral migratory stream. In particular, Rel A and p50 are expressed in radial glial cells, in migrating neuron precursors and in a population belonging to the astrocytic lineage. Rel B, on the other hand, is only expressed in migrating neuron precursors, whereas c-Rel is present in a few cells located at the edges of the rostral migratory stream. The expression of Rel A and p50 persists into adulthood, particularly in subventricular zone astrocyte-like cells and in migrating neuron precursors, respectively. The selective expression of NF-κB members in the postnatal subventricular zone and rostral migratory stream and their persistence into adulthood in regions of ongoing neurogenesis suggests possible mechanisms linking NF-κB expression with cell proliferation and migration. Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-κB may be part of a signaling pathway that is important for neurogenesis.
KW - Postnatal neurogenesis
KW - Radial glia
KW - Stem cell
KW - Subventricular zone
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=11144311868&partnerID=8YFLogxK
U2 - 10.1016/j.devbrainres.2004.10.010
DO - 10.1016/j.devbrainres.2004.10.010
M3 - Article
SN - 0165-3806
VL - 154
SP - 81
EP - 89
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 1
ER -