TY - JOUR
T1 - Mechanisms by which exercise training benefits patients with heart failure
AU - Crimi, Ettore
AU - Ignarro, Louis J.
AU - Cacciatore, Francesco
AU - Napoli, Claudio
N1 - Funding Information:
supported in part by a grant from the italian Ministery of University and research 2006 (PriN 2006, Principal investigator: Prof Napoli) and ricerca Finalizzata from italian Ministery of Health 2006 (Principal investigator: Dr Cacciatore).
PY - 2009/4
Y1 - 2009/4
N2 - Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of exercise tolerance. Regular exercise training is associated with health-improving effects. In patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and quality of life, as well as reduce hospitalization and, to some extent, risk of mortality. Progressive exercise training is associated with pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that increase oxygen delivery and energy production. This Review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on patients with heart failure.
AB - Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of exercise tolerance. Regular exercise training is associated with health-improving effects. In patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and quality of life, as well as reduce hospitalization and, to some extent, risk of mortality. Progressive exercise training is associated with pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that increase oxygen delivery and energy production. This Review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on patients with heart failure.
UR - http://www.scopus.com/inward/record.url?scp=67649644862&partnerID=8YFLogxK
U2 - 10.1038/nrcardio.2009.8
DO - 10.1038/nrcardio.2009.8
M3 - Review article
SN - 1759-5002
VL - 6
SP - 292
EP - 300
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 4
ER -