MDC/CCL22 intrathecal levels in patients with multiple sclerosis

Daniela Galimberti; C. Fenoglio; C. Comi; D. Scalabrini; M. De Riz; M. Leone; E. Venturelli; F. Cortini; M. Piola; F. Monaco; N. Bresolin; E. Scarpini

doi:10.1177/1352458507084268

MDC/CCL22 intrathecal levels in patients with multiple sclerosis

Daniela Galimberti, C. Fenoglio, C. Comi, D. Scalabrini, M. De Riz, M. Leone, E. Venturelli, F. Cortini, M. Piola, F. Monaco, N. Bresolin, E. Scarpini

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.

Lingua originale	Inglese
pagine (da-a)	547-549
Numero di pagine	3
Rivista	Multiple Sclerosis Journal
Volume	14
Numero di pubblicazione	4
DOI	https://doi.org/10.1177/1352458507084268
Stato di pubblicazione	Pubblicato - mag 2008

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10.1177/1352458507084268

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title = "MDC/CCL22 intrathecal levels in patients with multiple sclerosis",

abstract = "MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.",

keywords = "Cerebrospinal fluid, MDC/CCL22, Multiple sclerosis",

author = "Daniela Galimberti and C. Fenoglio and C. Comi and D. Scalabrini and \{De Riz\}, M. and M. Leone and E. Venturelli and F. Cortini and M. Piola and F. Monaco and N. Bresolin and E. Scarpini",

year = "2008",

month = may,

doi = "10.1177/1352458507084268",

language = "English",

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TY - JOUR

T1 - MDC/CCL22 intrathecal levels in patients with multiple sclerosis

AU - Galimberti, Daniela

AU - Fenoglio, C.

AU - Comi, C.

AU - Scalabrini, D.

AU - De Riz, M.

AU - Leone, M.

AU - Venturelli, E.

AU - Cortini, F.

AU - Piola, M.

AU - Monaco, F.

AU - Bresolin, N.

AU - Scarpini, E.

PY - 2008/5

Y1 - 2008/5

N2 - MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.

AB - MDC/CCL22 has been detected in the brain of mice with experimental autoimmune encephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiple sclerosis (MS) and in 17 controls. No significant differences were found, even when stratifying patients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22 levels were observed in female patients when compared with female controls and male patients (109.03 versus 98.54 and 99.37 pg/mL, P = 0.034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines.

KW - Cerebrospinal fluid

KW - MDC/CCL22

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/46749157569

U2 - 10.1177/1352458507084268

DO - 10.1177/1352458507084268

M3 - Article

SN - 1352-4585

VL - 14

SP - 547

EP - 549

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 4

ER -

MDC/CCL22 intrathecal levels in patients with multiple sclerosis

Abstract

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