TY - JOUR
T1 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen
AU - Bianca, C
AU - Chiacchio, F
AU - PAPPALARDO, FRANCESCO
AU - PENNISI, MARZIO ALFIO
N1 - Funding Information:
The first author was partially supported by the FIRB project-RBID08PP3J-Metodi matematici e relativi strumenti per la modellizzazione e la simulazione della formazione di tumori, competizione con il sistema immunitario, e conseguenti suggerimenti terapeutici. The research was also partially supported by the INDAM-GNFM-Young Researchers Project-prot. n.43-Mathematical Modelling for the Cancer-Immune System Competition Elicited by a Vaccine and by University of Catania under PRA grant. The authors would like to thank Prof. P.L. Lollini and coworkers for supplying data and Prof. S. Motta for useful discussions.
PY - 2012
Y1 - 2012
N2 - The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.
AB - The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.
UR - https://iris.uniupo.it/handle/11579/118129
U2 - 10.1186/1471-2105-13-S17-S21
DO - 10.1186/1471-2105-13-S17-S21
M3 - Article
SN - 1471-2105
VL - 13
JO - BMC Bioinformatics
JF - BMC Bioinformatics
IS - Suppl 17:S21
ER -
