Mathematical modeling of the immune system recognition to mammary carcinoma antigen

Carlo Bianca; Ferdinando Chiacchio; Francesco Pappalardo; Marzio Pennisi

doi:10.1186/1471-2105-13-S17-S21

Mathematical modeling of the immune system recognition to mammary carcinoma antigen

Carlo Bianca
, Ferdinando Chiacchio
, Francesco Pappalardo
, Marzio Pennisi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.

Lingua originale	Inglese
Numero di articolo	S21
Rivista	BMC Bioinformatics
Volume	13
Numero di pubblicazione	SUPPL.17
DOI	https://doi.org/10.1186/1471-2105-13-S17-S21
Stato di pubblicazione	Pubblicato - 13 dic 2012
Pubblicato esternamente	Sì

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10.1186/1471-2105-13-S17-S21

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title = "Mathematical modeling of the immune system recognition to mammary carcinoma antigen",

abstract = "The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.",

author = "Carlo Bianca and Ferdinando Chiacchio and Francesco Pappalardo and Marzio Pennisi",

note = "Funding Information: The first author was partially supported by the FIRB project-RBID08PP3J-Metodi matematici e relativi strumenti per la modellizzazione e la simulazione della formazione di tumori, competizione con il sistema immunitario, e conseguenti suggerimenti terapeutici. The research was also partially supported by the INDAM-GNFM-Young Researchers Project-prot. n.43-Mathematical Modelling for the Cancer-Immune System Competition Elicited by a Vaccine and by University of Catania under PRA grant. The authors would like to thank Prof. P.L. Lollini and coworkers for supplying data and Prof. S. Motta for useful discussions.",

year = "2012",

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doi = "10.1186/1471-2105-13-S17-S21",

language = "English",

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journal = "BMC Bioinformatics",

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T1 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen

AU - Bianca, Carlo

AU - Chiacchio, Ferdinando

AU - Pappalardo, Francesco

AU - Pennisi, Marzio

N1 - Funding Information: The first author was partially supported by the FIRB project-RBID08PP3J-Metodi matematici e relativi strumenti per la modellizzazione e la simulazione della formazione di tumori, competizione con il sistema immunitario, e conseguenti suggerimenti terapeutici. The research was also partially supported by the INDAM-GNFM-Young Researchers Project-prot. n.43-Mathematical Modelling for the Cancer-Immune System Competition Elicited by a Vaccine and by University of Catania under PRA grant. The authors would like to thank Prof. P.L. Lollini and coworkers for supplying data and Prof. S. Motta for useful discussions.

PY - 2012/12/13

Y1 - 2012/12/13

N2 - The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.

AB - The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.

UR - https://www.scopus.com/pages/publications/84870253722

U2 - 10.1186/1471-2105-13-S17-S21

DO - 10.1186/1471-2105-13-S17-S21

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JF - BMC Bioinformatics

IS - SUPPL.17

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ER -

Mathematical modeling of the immune system recognition to mammary carcinoma antigen

Abstract

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