Mast cell and neutrophil interactions: A role for superoxide anion and histamine

R. Fantozzi; S. Brunelleschi; L. Giuliattini; P. Blandina; E. Masini; G. Cavallo; P. F. Mannaioni

doi:10.1007/BF01983155

Mast cell and neutrophil interactions: A role for superoxide anion and histamine

R. Fantozzi, S. Brunelleschi, L. Giuliattini, P. Blandina, E. Masini, G. Cavallo, P. F. Mannaioni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Histamine inhibits superoxide anion (O₂^-) production from human neutrophils stimulated by N-formylmethionlyleucyl-phenylalanine (FMLP). The effects of histamine are dose-dependent and competitively antagonized by cimetidine. When passively sensitized rat serosal mast cells and human neutrophils are mixed together, O₂^- production from FMLP-activated granulocytes is significantly reduced, following mast cell degranulation by acetylcholine. These inhibitory effects can be counteracted by cimetidine. Exposure of non-sensitized rat mast cells to FMLP-stimulated human neutrophils causes histamine release. These results suggest bidirectional control mechanisms between mast cells and neutrophils, that further stress the role of histamine in regulating inflammatory processes.

Lingua originale	Inglese
pagine (da-a)	260-264
Numero di pagine	5
Rivista	Agents and Actions
Volume	16
Numero di pubblicazione	3-4
DOI	https://doi.org/10.1007/BF01983155
Stato di pubblicazione	Pubblicato - apr 1985
Pubblicato esternamente	Sì

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title = "Mast cell and neutrophil interactions: A role for superoxide anion and histamine",

abstract = "Histamine inhibits superoxide anion (O2-) production from human neutrophils stimulated by N-formylmethionlyleucyl-phenylalanine (FMLP). The effects of histamine are dose-dependent and competitively antagonized by cimetidine. When passively sensitized rat serosal mast cells and human neutrophils are mixed together, O2- production from FMLP-activated granulocytes is significantly reduced, following mast cell degranulation by acetylcholine. These inhibitory effects can be counteracted by cimetidine. Exposure of non-sensitized rat mast cells to FMLP-stimulated human neutrophils causes histamine release. These results suggest bidirectional control mechanisms between mast cells and neutrophils, that further stress the role of histamine in regulating inflammatory processes.",

author = "R. Fantozzi and S. Brunelleschi and L. Giuliattini and P. Blandina and E. Masini and G. Cavallo and Mannaioni, {P. F.}",

year = "1985",

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doi = "10.1007/BF01983155",

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T1 - Mast cell and neutrophil interactions

T2 - A role for superoxide anion and histamine

AU - Fantozzi, R.

AU - Brunelleschi, S.

AU - Giuliattini, L.

AU - Blandina, P.

AU - Masini, E.

AU - Cavallo, G.

AU - Mannaioni, P. F.

PY - 1985/4

Y1 - 1985/4

N2 - Histamine inhibits superoxide anion (O2-) production from human neutrophils stimulated by N-formylmethionlyleucyl-phenylalanine (FMLP). The effects of histamine are dose-dependent and competitively antagonized by cimetidine. When passively sensitized rat serosal mast cells and human neutrophils are mixed together, O2- production from FMLP-activated granulocytes is significantly reduced, following mast cell degranulation by acetylcholine. These inhibitory effects can be counteracted by cimetidine. Exposure of non-sensitized rat mast cells to FMLP-stimulated human neutrophils causes histamine release. These results suggest bidirectional control mechanisms between mast cells and neutrophils, that further stress the role of histamine in regulating inflammatory processes.

AB - Histamine inhibits superoxide anion (O2-) production from human neutrophils stimulated by N-formylmethionlyleucyl-phenylalanine (FMLP). The effects of histamine are dose-dependent and competitively antagonized by cimetidine. When passively sensitized rat serosal mast cells and human neutrophils are mixed together, O2- production from FMLP-activated granulocytes is significantly reduced, following mast cell degranulation by acetylcholine. These inhibitory effects can be counteracted by cimetidine. Exposure of non-sensitized rat mast cells to FMLP-stimulated human neutrophils causes histamine release. These results suggest bidirectional control mechanisms between mast cells and neutrophils, that further stress the role of histamine in regulating inflammatory processes.

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U2 - 10.1007/BF01983155

DO - 10.1007/BF01983155

M3 - Article

SN - 0065-4299

VL - 16

SP - 260

EP - 264

JO - Agents and Actions

JF - Agents and Actions

IS - 3-4

ER -

Mast cell and neutrophil interactions: A role for superoxide anion and histamine

Abstract

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