Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

L. Corrado; P. Colapietro; L. Larizza; P. Riva

doi:10.1006/mcpr.1999.0237

Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

L. Corrado, P. Colapietro, L. Larizza, P. Riva

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

Lingua originale	Inglese
pagine (da-a)	199-202
Numero di pagine	4
Rivista	Molecular and Cellular Probes
Volume	13
Numero di pubblicazione	3
DOI	https://doi.org/10.1006/mcpr.1999.0237
Stato di pubblicazione	Pubblicato - giu 1999
Pubblicato esternamente	Sì

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10.1006/mcpr.1999.0237

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title = "Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR",

abstract = "The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.",

keywords = "Human WHN gene, Retinal 4 gene, STR, Sodium/dicarboxylate cotransporter gene, YAC contig",

author = "L. Corrado and P. Colapietro and L. Larizza and P. Riva",

note = "Funding Information: The authors thank Marco Venturin and Raffaella Macchi for their technical support. This work was supported by MURST 40%: {\textquoteleft}Applicazioni Biomediche nella Biologia Molecolare{\textquoteright} (to LL) and by Fondazione T{\'e}l{\'e}thon-Italy, grant E. 780 (to LL and PR).",

year = "1999",

month = jun,

doi = "10.1006/mcpr.1999.0237",

language = "English",

volume = "13",

pages = "199--202",

journal = "Molecular and Cellular Probes",

issn = "0890-8508",

publisher = "Academic Press",

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TY - JOUR

T1 - Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

AU - Corrado, L.

AU - Colapietro, P.

AU - Larizza, L.

AU - Riva, P.

N1 - Funding Information: The authors thank Marco Venturin and Raffaella Macchi for their technical support. This work was supported by MURST 40%: ‘Applicazioni Biomediche nella Biologia Molecolare’ (to LL) and by Fondazione Téléthon-Italy, grant E. 780 (to LL and PR).

PY - 1999/6

Y1 - 1999/6

N2 - The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

AB - The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

KW - Human WHN gene

KW - Retinal 4 gene

KW - STR

KW - Sodium/dicarboxylate cotransporter gene

KW - YAC contig

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U2 - 10.1006/mcpr.1999.0237

DO - 10.1006/mcpr.1999.0237

M3 - Article

SN - 0890-8508

VL - 13

SP - 199

EP - 202

JO - Molecular and Cellular Probes

JF - Molecular and Cellular Probes

IS - 3

ER -

Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

Abstract

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