Macrophages in cancer and infectious diseases: The 'good' and the 'bad'

Chiara Porta; Elena Riboldi; Maria Grazia Totaro; Laura Strauss; Antonio Sica; Alberto Mantovani

doi:10.2217/imt.11.116

Macrophages in cancer and infectious diseases: The 'good' and the 'bad'

Chiara Porta, Elena Riboldi, Maria Grazia Totaro, Laura Strauss, Antonio Sica, Alberto Mantovani

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.

Lingua originale	Inglese
pagine (da-a)	1185-1202
Numero di pagine	18
Rivista	Immunotherapy
Volume	3
Numero di pubblicazione	10
DOI	https://doi.org/10.2217/imt.11.116
Stato di pubblicazione	Pubblicato - ott 2011

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title = "Macrophages in cancer and infectious diseases: The 'good' and the 'bad'",

abstract = "Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.",

keywords = "HIV-1, Mycobacterium tuberculosis, Tie2-expressing monocytes, cancer-related inflammation, chemokines, macrophages, parasites infections, polarized inflammation, tumor-associated macrophages",

author = "Chiara Porta and Elena Riboldi and Totaro, {Maria Grazia} and Laura Strauss and Antonio Sica and Alberto Mantovani",

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AU - Strauss, Laura

AU - Sica, Antonio

AU - Mantovani, Alberto

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AB - Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.

KW - HIV-1

KW - Mycobacterium tuberculosis

KW - Tie2-expressing monocytes

KW - cancer-related inflammation

KW - chemokines

KW - macrophages

KW - parasites infections

KW - polarized inflammation

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Macrophages in cancer and infectious diseases: The 'good' and the 'bad'

Abstract

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