Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray; Judith E. Allen; Subhra K. Biswas; Edward A. Fisher; Derek W. Gilroy; Sergij Goerdt; Siamon Gordon; John A. Hamilton; Lionel B. Ivashkiv; Toby Lawrence; Massimo Locati; Alberto Mantovani; Fernando O. Martinez; Jean Louis Mege; David M. Mosser; Gioacchino Natoli; Jeroen P. Saeij; Joachim L. Schultze; Kari Ann Shirey; Antonio Sica; Jill Suttles; Irina Udalova; Jo A. vanGinderachter; Stefanie N. Vogel; Thomas A. Wynn

doi:10.1016/j.immuni.2014.06.008

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray, Judith E. Allen, Subhra K. Biswas, Edward A. Fisher, Derek W. Gilroy, Sergij Goerdt, Siamon Gordon, John A. Hamilton, Lionel B. Ivashkiv, Toby Lawrence, Massimo Locati, Alberto Mantovani, Fernando O. Martinez, Jean Louis Mege, David M. Mosser, Gioacchino Natoli, Jeroen P. Saeij, Joachim L. Schultze, Kari Ann Shirey, Antonio SicaJill Suttles, Irina Udalova, Jo A. vanGinderachter, Stefanie N. Vogel, Thomas A. Wynn

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.

Lingua originale	Inglese
pagine (da-a)	14-20
Numero di pagine	7
Rivista	Immunity
Volume	41
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/j.immuni.2014.06.008
Stato di pubblicazione	Pubblicato - 17 lug 2014

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Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., Locati, M., Mantovani, A., Martinez, F. O., Mege, J. L., Mosser, D. M., Natoli, G., Saeij, J. P., Schultze, J. L., Shirey, K. A., ... Wynn, T. A. (2014). Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines. Immunity, 41(1), 14-20. https://doi.org/10.1016/j.immuni.2014.06.008

@article{129d4f1c7bca40648bacf8285bb792e9,

title = "Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines",

abstract = "Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.",

author = "Murray, {Peter J.} and Allen, {Judith E.} and Biswas, {Subhra K.} and Fisher, {Edward A.} and Gilroy, {Derek W.} and Sergij Goerdt and Siamon Gordon and Hamilton, {John A.} and Ivashkiv, {Lionel B.} and Toby Lawrence and Massimo Locati and Alberto Mantovani and Martinez, {Fernando O.} and Mege, {Jean Louis} and Mosser, {David M.} and Gioacchino Natoli and Saeij, {Jeroen P.} and Schultze, {Joachim L.} and Shirey, {Kari Ann} and Antonio Sica and Jill Suttles and Irina Udalova and vanGinderachter, {Jo A.} and Vogel, {Stefanie N.} and Wynn, {Thomas A.}",

note = "Funding Information: This work was supported by NIH grants AI062921 (P.J.M.), AI080621 (J.P.S.), HL084312 (E.A.F.), and AI18797 (K.A.S. and S.N.V.), Alex{\textquoteright}s Lemonade Stand Foundation (P.J.M.), the Hartwell Foundation (P.J.M.), Cancer Center Core grant P30 CA21765 (P.J.M.), the American Lebanese Syrian Associated Charities (P.J.M.), and the NIH Intramural Program (T.A.W.).",

year = "2014",

month = jul,

day = "17",

doi = "10.1016/j.immuni.2014.06.008",

language = "English",

volume = "41",

pages = "14--20",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "1",

}

Murray, PJ, Allen, JE, Biswas, SK, Fisher, EA, Gilroy, DW, Goerdt, S, Gordon, S, Hamilton, JA, Ivashkiv, LB, Lawrence, T, Locati, M, Mantovani, A, Martinez, FO, Mege, JL, Mosser, DM, Natoli, G, Saeij, JP, Schultze, JL, Shirey, KA, Sica, A, Suttles, J, Udalova, I, vanGinderachter, JA, Vogel, SN & Wynn, TA 2014, 'Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines', Immunity, vol. 41, n. 1, pagg. 14-20. https://doi.org/10.1016/j.immuni.2014.06.008

TY - JOUR

T1 - Macrophage Activation and Polarization

T2 - Nomenclature and Experimental Guidelines

AU - Murray, Peter J.

AU - Allen, Judith E.

AU - Biswas, Subhra K.

AU - Fisher, Edward A.

AU - Gilroy, Derek W.

AU - Goerdt, Sergij

AU - Gordon, Siamon

AU - Hamilton, John A.

AU - Ivashkiv, Lionel B.

AU - Lawrence, Toby

AU - Locati, Massimo

AU - Mantovani, Alberto

AU - Martinez, Fernando O.

AU - Mege, Jean Louis

AU - Mosser, David M.

AU - Natoli, Gioacchino

AU - Saeij, Jeroen P.

AU - Schultze, Joachim L.

AU - Shirey, Kari Ann

AU - Sica, Antonio

AU - Suttles, Jill

AU - Udalova, Irina

AU - vanGinderachter, Jo A.

AU - Vogel, Stefanie N.

AU - Wynn, Thomas A.

N1 - Funding Information: This work was supported by NIH grants AI062921 (P.J.M.), AI080621 (J.P.S.), HL084312 (E.A.F.), and AI18797 (K.A.S. and S.N.V.), Alex’s Lemonade Stand Foundation (P.J.M.), the Hartwell Foundation (P.J.M.), Cancer Center Core grant P30 CA21765 (P.J.M.), the American Lebanese Syrian Associated Charities (P.J.M.), and the NIH Intramural Program (T.A.W.).

PY - 2014/7/17

Y1 - 2014/7/17

N2 - Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.

AB - Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments invitro and invivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature. The description of macrophage activation status is contentious and confusing. Murray etal. propose a framework for macrophage-activation nomenclature.

UR - http://www.scopus.com/inward/record.url?scp=84904394690&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2014.06.008

DO - 10.1016/j.immuni.2014.06.008

M3 - Review article

SN - 1074-7613

VL - 41

SP - 14

EP - 20

JO - Immunity

JF - Immunity

IS - 1

ER -

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

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