@article{58c105a3d36649159a80f9162a3301c3,
title = "Macrocyclic diterpenoids from Euphorbia hyberna L. subsp. insularis and their reaction with oxyphilic reagents",
abstract = "The aerial parts of Euphorbia hyberna subsp. insularis from Sardinia contain large amounts of macrocyclic diterpenoids of the jatrophane type, while phorboids could not be isolated. Treatment of the major constituent (1a) with various acidic and oxyphilic reagents was investigated, showing the surprising reluctance of the macrocyclic system to undergo transannular reactions. Dehydration, isomerization of the exocyclic double and acyl rearrangement were, however, observed after reduction of the 9-keto group.",
keywords = "Chemotaxonomy, Diterpenoids, Euphorbia hyberna subsp. insularis, Jatrophanes, Phorboids",
author = "G. Appendino and P. Spagliardi and M. Ballero and G. Seu",
note = "Funding Information: This work was supported by MURST (Fondi ex-40%, Progetto Sostanze Naturali e Analoghi Sintetici con Attivit{\`a} Antitumorale). We are grateful to Dr Jasmin Jakupovic (AnalytiCon Discovery, Potsdam, Germany) for useful discussions on the structure elucidation of the compounds and to Dr R. Sestu and the Pro Loco Arzana for their hospitality and help during the collection of the plant material. ",
year = "2002",
month = dec,
doi = "10.1016/S0367-326X(02)00213-7",
language = "English",
volume = "73",
pages = "576--582",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier B.V.",
number = "7-8",
}