Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Filippo Renò; Manuela Rizzi; Marco Invernizzi; Mario Migliario; Carlo Cisari

doi:10.1016/j.ejphar.2013.08.044

Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Filippo Renò, Manuela Rizzi, Marco Invernizzi, Mario Migliario, Carlo Cisari

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

Lingua originale	Inglese
pagine (da-a)	301-304
Numero di pagine	4
Rivista	European Journal of Pharmacology
Volume	721
Numero di pubblicazione	1-3
DOI	https://doi.org/10.1016/j.ejphar.2013.08.044
Stato di pubblicazione	Pubblicato - 5 dic 2013

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10.1016/j.ejphar.2013.08.044

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title = "Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor",

abstract = "Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.",

keywords = "Amino-bisphosphonate, Glucocorticoid receptor, Human keratinocyte",

author = "Filippo Ren{\`o} and Manuela Rizzi and Marco Invernizzi and Mario Migliario and Carlo Cisari",

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doi = "10.1016/j.ejphar.2013.08.044",

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AU - Renò, Filippo

AU - Rizzi, Manuela

AU - Invernizzi, Marco

AU - Migliario, Mario

AU - Cisari, Carlo

PY - 2013/12/5

Y1 - 2013/12/5

N2 - Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

AB - Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

KW - Amino-bisphosphonate

KW - Glucocorticoid receptor

KW - Human keratinocyte

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DO - 10.1016/j.ejphar.2013.08.044

M3 - Article

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VL - 721

SP - 301

EP - 304

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-3

ER -

Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Abstract

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