TY - JOUR
T1 - Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
AU - Bellan, Mattia
AU - Baricich, Alessio
AU - Patrucco, Filippo
AU - Zeppegno, Patrizia
AU - Gramaglia, Carla
AU - Balbo, Piero Emilio
AU - Carriero, Alessandro
AU - Amico, Chiara Santa
AU - Avanzi, Gian Carlo
AU - Barini, Michela
AU - Battaglia, Marco
AU - Bor, Simone
AU - Cantaluppi, Vincenzo
AU - Cappellano, Giuseppe
AU - Ceruti, Federico
AU - Chiocchetti, Annalisa
AU - Clivati, Elisa
AU - Giordano, Mara
AU - Cuneo, Daria
AU - Gambaro, Eleonora
AU - Gattoni, Eleonora
AU - Loro, Alberto
AU - Manfredi, Marcello
AU - Morosini, Umberto
AU - Murano, Francesco
AU - Paracchini, Elena
AU - Patti, Giuseppe
AU - Pinato, David James
AU - Raineri, Davide
AU - Rolla, Roberta
AU - Sainaghi, Pier Paolo
AU - Tricca, Stefano
AU - Pirisi, Mario
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
AB - Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
U2 - 10.1038/s41598-021-01215-4
DO - 10.1038/s41598-021-01215-4
M3 - Article
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 22666
ER -